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. 2022 Jan 7;12:138. doi: 10.1038/s41598-021-03947-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Elimination of CPNS1 decreases cytochrome c loss and PARP activation during ISC–REP. In wild type mice, ISC–REP led to increased cytochrome c content in cytosol compared to time control (a,c). However, ISC–REP did not increase cytochrome c content in cytosol in KO (knockout) mice compared to time control (b,d). These results suggest that elimination of CPNS1 maintained mitochondrial outer membrane integrity during ISC–REP. In wild type mice, ISC–REP led to increased PARP cleavage compared to time control (e,g). However, ISC–REP did not increase PARP cleavage in KO mice compared to time control (f,h), indicating that elimination of CPNS1 prevented AIF-mediated PARP cleavage during ISC–REP. Data are expressed as mean ± SD; *p < 0.05 vs. time control. n = 4 in each group. Not every sample was used for immunoblotting in each group.