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. 2022 Jan 7;12:138. doi: 10.1038/s41598-021-03947-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of proteomic data with Ingenuity Pathway Analysis (IPA) in WT and CPNS1 KO (knockout) mitochondria. (a) Predicted effects using WT:IR/TC data in the proteins-IR network. (b) Predicted effects using KO:IR/TC data in the proteins-IR network. (c) Predicted effects using IR: KO/WT data in the proteins-IR network. The figure was generated in Qiagen Ingenuity Pathway Analysis (IPA) program using several differentially expressed proteins (pink or red for upregulated protein, green for downregulated proteins) and their relationships to reperfusion injury of heart. The relationships and several mediating proteins, complexes or endogenous chemicals were added using the Pathway Explorer tool in IPA, and the predicted effects (orange for activation, blue for inhibition, yellow indicates the finding is inconsistent with the state of downstream molecule, and grey for no prediction) were made by the Molecule Activity Predictor (MAP) of IPA. Relationships: Direct interaction. Indirect interaction. activation, causation, expression, localization, membership, modification, phosphorylation, regulation of binding, transcription. inhibition, ubiquitination.

Inline graphic — Analysis of proteomic data with Ingenuity Pathway Analysis (IPA) in WT and CPNS1 KO (knockout) mitochondria. (a) Predicted effects using WT:IR/TC data in the proteins-IR network. (b) Predicted effects using KO:IR/TC data in the proteins-IR network. (c) Predicted effects using IR: KO/WT data in the proteins-IR network. The figure was generated in Qiagen Ingenuity Pathway Analysis (IPA) program using several differentially expressed proteins (pink or red for upregulated protein, green for downregulated proteins) and their relationships to reperfusion injury of heart. The relationships and several mediating proteins, complexes or endogenous chemicals were added using the Pathway Explorer tool in IPA, and the predicted effects (orange for activation, blue for inhibition, yellow indicates the finding is inconsistent with the state of downstream molecule, and grey for no prediction) were made by the Molecule Activity Predictor (MAP) of IPA. Relationships: Direct interaction. Indirect interaction. activation, causation, expression, localization, membership, modification, phosphorylation, regulation of binding, transcription. inhibition, ubiquitination.