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. 2022 Jan 7;12:42. doi: 10.1038/s41598-021-03964-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heatmap visualizing the clustering of primary UM (P) and UM metastases (M) based on DMR with a FC > 5. SF3B1-mutated primary UM show a similar methylome as SF3B1-mutated metastases and the same is observed for the BAP1-mutated primary UM and BAP1-mutated metastases. Red indicates hypermethylation, whereas blue indicated hypomethylation of the DMR. Matched primary UM and metastases samples are marked by their sample number (UM23, UM27, UM28, UM29, UM9, UM13, UM14).