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. 2022 Jan 7;12:152. doi: 10.1038/s41598-021-03886-5

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Small intestinal tight junctions are reduced in SFB colonized NZM2410 mice. (A) ZO-1 tight junction scaffolding protein (red) is decreased in +SFB mice at 30 weeks of age. (B) Claudin-1 (bottom panels; red) and Claudin-3 (bottom panels; green) tight junctions were also decreased in +SFB mice at the same time point. Standardized fluorescence intensity analyses are shown below. C. Intestinal permeability is increased in SFB-colonized mice as measured by Dextran-FITC fluorescence. Error bars represent mean ± SEM (A–C). Unpaired Student t test (A–C). *p < 0.05.