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. 2022 Jan 7;12:134. doi: 10.1038/s41598-021-04075-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Adjusted drug retention by TNFi, aIL-6R, CTLA4-Ig and JAKi experience. Adjusted drug retention due to lack of effectiveness between (a) non-TNFi-experienced, prior TNFi intolerance, and prior TNFi ineffectiveness groups, (b) non-aIL-6R-experienced, prior aIL-6R intolerance, and prior aIL-6R ineffectiveness groups, (c) non-CTLA4-Ig-experienced, prior CTLA4-Ig intolerance, and prior CTLA4-Ig ineffectiveness groups, (d) and non-JAKi-experienced, prior JAKi intolerance, and prior JAKi ineffectiveness groups. TNFi tumour necrosis factor inhibitor, aIL-6R anti-interleukin-6 receptor, CTLA4-Ig cytotoxic T lymphocyte-associated antigen-4-Ig, JAKi Janus kinase inhibitor.