Table 3.
Before PS matching | After PS matching | |||||
---|---|---|---|---|---|---|
Outcome | IFN (n = 92) | DAA (n = 82) | p value | IFN (n = 42) | DAA (n = 42) | p value |
Change of LS value† at 48 W, kPa (%) | 0.62 ± 1.39 (8%) | 5.78 ± 7.69 (27%) | < 0.0001 | 0.75 ± 1.68 (9%) | 5.74 ± 8.53 (29%) | < 0.0001 |
Change of LS value at 96 W, kPa (%) | 1.46 ± 2.79 (15%) | 7.92 ± 8.28 (37%) | < 0.0001 | 1.55 ± 2.85 (17%) | 7.11 ± 8.44 (39%) | 0.0001 |
Significant regression‡ at 48 W | 5 (5.5) | 40 (48.8) | < 0.0001 | 3 (7.1) | 23 (54.8) | < 0.0001 |
Significant regression at 96 W | 12 (13.2) | 52 (63.4) | < 0.0001 | 5 (15.6) | 27 (64.3) | < 0.0001 |
†Changes of LS value are described as subtracted change from baseline LS (percentage change).
‡Significant regression was defined as more than 30% reduction of liver stiffness from baseline.
PS, propensity matching; IFN, interferon; DAA, direct antiviral agents; LS, liver stiffness; W, week.