Table 2.
Univariate and multivariate logistic regression analysis of predictive factors for ALT/WDLS.
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| Odds ratio (95% CI) | p value | Odds ratio (95% CI) | p value | Standard partial regression coefficient |
|
| Clinical findings | |||||
| Age | 4.26 (1.87–9.74) | < 0.001 | 4.16 (0.93–18.60) | 0.062 | 1.425 |
| Sex | 1.30 (0.67–2.56) | 0.440 | |||
| Symptoms | 2.55 (0.69–9.47) | 0.162 | |||
| Tumor site | |||||
| Lower limb vs Upper limb or Other | 6.21 (2.97–13.00) | < 0.0001 | 5.51 (1.51–20.10) | 0.001 | 1.706 |
| Depth | > 1000 (0.00-Inf) | < 0.0001 | > 1000 (0.00-Inf) | < 0.0001 | 18.829 |
| Tumor size (> 11 cm) | 12.40 (5.20–29.60) | < 0.0001 | 4.83 (1.37–17.00) | 0.014 | 1.574 |
| MRI findings | |||||
| Thick septa (> 2 mm) | 9.25 (3.08–27.80) | < 0.0001 | 5.56 (1.09–28.30) | 0.039 | 1.715 |
| Enhancement (septa or nodular lesion) | 24.50 (7.90–76.10) | < 0.0001 | 15.10 (2.91–77.90) | 0.001 | 2.711 |
| Neurovascular involvement | 8.63 (0.98–75.90) | 0.052 | |||
| Histopathological findings | |||||
| Nuclear atypia | > 1000 (0.00-Inf) | < 0.0001 | |||
| Nuclear enlargement | 8.77 (3.58–21.50) | < 0.0001 | 1.69 (0.40–7.17) | 0.480 | 0.521 |
| Difference in size of adipocytes | 2.35 (1.16–4.74) | 0.018 | 0.91 (0.26–3.20) | 0.888 | − 0.090 |
| Proliferation of fibrous septa | 1.06 (0.17–6.56) | 0.949 | |||
| Lipoblasts | 21.5 (2.69–172.00) | 0.004 | 17.60 (1.08–286.00) | 0.043 | 2.548 |
| FISH | |||||
| MDM2 and/or CDK4 | > 1000 (0.00-Inf) | < 0.0001 | |||
MRI magnetic resonance imaging, CI confidence interval, Inf infinity, ALT atypical lipomatous tumor, WDLS well-differentiated liposarcoma, FISH Fluorescence in Situ Hybridization, MDM2 murine double-minute 2, CDK4 cyclin-dependent kinase 4.