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No obvious toxicity of ATRA on mice bearing HepG2 tumors. (A) Mice weight in different treatment groups was measured every 2 days during experiment; (B) H&E staining for tissues of heart, liver, spleen, lung and kidney demonstrated no obvious histopathological damage to the important organs in the indicated groups (200×). RFA, radiofrequency ablation; ATRA, all-trans retinoic acid; IRFA, insufficient radiofrequency ablation; H&E, hematoxylin & eosin.
