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. 2021 Nov 28;26(1):186–194. doi: 10.1111/jcmm.17071

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© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Protein network analysis of 1340 unique target genes. (A) Protein‐protein‐interaction (PPI) network constructed using STRING database and visualized by NetworkAnalyst. The degree of connectivity is shown by the size of the node, with larger circles indicating greater connectivity. The colour of the node represents the value of the betweenness from red (large) to purple (small). (B, C) Top two clusters of functional modules as determined by using the Molecular Complex Detection (MCODE) plug‐in of Cytoscape (version 3.8.0)