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. 2021 Nov 28;26(1):186–194. doi: 10.1111/jcmm.17071

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© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Network of the top 10 hub genes based on cytoHubba plug‐in of Cytoscape. (A) The expanded subnetwork is displayed. The warm colours represent the genes; the blue circles represent genes that directly interact with them. (B) The shortest path is displayed. The darker the node, the higher the ranking using the degree algorithm. (C) Network map of miRNA–hub gene interactions. Rbx1, Fbxl3, Fbxo27, Cul3, Cul2, Klhl42, Klhl5 and Fbxl16 are target genes of mmu‐miR‐338‐5p; Fbxo4 and Fbxl7 are target genes of mmu‐miR‐1936; mmu‐miR‐673‐3p has no target genes that is the core gene in the molecular network