FIGURE 6.

ox‐LDL‐M‐EVs carrying miR‐19b‐3p aggravate atherosclerosis in ApoE^−/− mice. (A) The expression of α‐SMA and CD9 in mouse aorta as measured by immunofluorescence. (B) The expression of miR‐19b‐3p as determined by RT‐qPCR. (C) Quantitative analysis results of JAZF1 expression in aorta of mice with different treatment as measured by immunohistochemistry (n = 10). *p < 0.05. (D) The protein expression of JAZF1 in aortas of ApoE^−/− mice as determined by western blot assay. (E) Quantitative analysis results of HE and oil red O staining for aortic plaque area and lipid deposition, lesion size and lumen area percentage in ApoE^−/− mice (n = 10). *p < 0.05 versus ND. ^# p < 0.05 versus HFD. ^& p < 0.05 versus HFD + ox‐LDL‐M‐EVs. The measurement data were expressed as mean ± standard deviation. One‐way ANOVA was conducted for comparing data between multiple groups, followed by Tukey's post hoc test