TABLE 1.

Participant exclusion criteria used in this study and the number of excluded participants

Exclusion criterion	Implementation of the exclusion criterion based on HCP measurements	Number of excluded participants
Handedness
1. Not right-handed	Handedness <0	117
Diagnosis on drug addiction
2. Meeting cannabis dependence	SSAGA_Mj_Ab_Dep = one (1)	102
3. Meeting Fagerstrom nicotine dependence	SSAGA_FTND_Score = 4+	48
4. Meeting Fagerstrom tobacco dependence	SSAGA_HSI_Score = 4	0
Times of drug use
5. Times used cocaine more than six times	SSAGA_Times_Used_Cocaine = 5	15
6. Times used hallucinogens more than six times	SSAGA_Times_Used_Hallucinogens = 5	1
7. Times used opiates more than six times	SSAGA_Times_Used_Opiates = 5	8
8. Times used sedatives more than six times	SSAGA_Times_Used_Sedatives = 5	1
9. Times used stimulants more than six times	SSAGA_Times_Used_Stimulants = 5	7
10. Times used marijuana more than 999 times	SSAGA_Mj_Times_Used = 5	22
Breath and urine test
11. Alcohol breath test	Breathalyzer_Over_05 = "TRUE"	1
12. Positive urine test for THC	THC = "TRUE"	42
13. Positive urine test for cocaine	Cocaine = "TRUE"	0
14. Positive urine test for opiates	Opiates = "TRUE"	3
15. Positive urine test for amphetamines	Amphetamines = "TRUE"	4
16. Positive urine test for MethAmphetamine	MethAmphetamine = "TRUE"	1
17. Positive urine test for Oxycontin	Oxycontin = "TRUE"	1
Data availability
18. Missing the measure of "total times used/smoked ANY	Total_Any_Tobacco_7days = space (i.e., " ")	19
TOBACCO in past 7 days"
19. Incentive-processing task fM RI data are not complete	fMRI_Gamb_PctCompl <100%	75

The exclusion criteria were applied to all the 1206 HCP participants one by one (the number in the “Exclusion criterion” column represents the order of the exclusion criteria applied), resulting 739 participants remaining for subsequent consideration after excluding 467 participants who met at least one of the 18 exclusion criteria.