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. 2021 Dec 16;40(12):1457–1461. doi: 10.1089/dna.2021.0659

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© Andrea C. Chaikovsky et al. 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

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FIG. 1. — AMBRA1 in cancer. CRL4^AMBRA1 ubiquitylates cyclin D for proteasomal degradation. Loss of AMBRA1 leads to high levels of cyclin D, which promotes the growth of multiple cancer types, such as DLBCL and LUAD, and decreases the sensitivity of cancer cells to CDK4/6 inhibitors. Created with BioRender.com. DLBCL, diffuse large B cell lymphoma; LUAD, lung adenocarcinoma.