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. 2021 Dec 16;40(12):1457–1461. doi: 10.1089/dna.2021.0659

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© Andrea C. Chaikovsky et al. 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

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FIG. 2. — A potential new model of cyclin D ubiquitylation. Schematics of the current (left) and revised (right) models of cyclin D ubiquitylation. Identification of CRL4^AMBRA1 as the main regulator of cyclin D stability suggests that cyclin D ubiquitylation occurs in the nucleus and may occur throughout the cell cycle. The identity of the major cyclin D kinase(s) warrants further investigation. Created with BioRender.com.