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. 2022 Jan 7;9:2. doi: 10.1186/s40662-021-00272-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Time course of corneal ulcers in the PACK-CXL group. a Patient presenting with a large corneal ulcer in the left nasal inferior cornea. b Marked reduction of the epithelial defect and beginning reorganization at day 7 after PACK-CXL. c Completed epithelial closure and beginning scar formation. d Round and opaque ulcer in the left upper temporal cornea. e At day 7 after PACK-CXL, the opacity starts resolving from the temporal edge. Of note, there is a slight transient clinical worsening of the temporal lesion border due to the Jarisch–Herxheimer reaction. f At 28 days after PACK-CXL, infiltrate regression and full epithelial closure with beginning scar formation are noted. PACK-CXL photoactivated chromophore corneal cross-linking