Fig. 1.

The activation and function of several cell types in a low fat diet (LFD) and high fat diet (HFD micro-environment. In a LFD and low cholesterol micro-environment, MSCs were prone to differentiate into osteoblasts with low pre-osteoclast formation and molecular and cellar signal and a high osteoblastic signal. In this state, due to low adipose derived cytokines, osteoblasts and osteoclasts were toned well with several cells taken part in, such as collar cell and B cells. However, in a high fatty diet, MSCs in the cell niche were exposed to a high fatty signal, making them more likely to differentiate to adipocytes. Adipocytes then become another vital source of RANKL, a molecule that is necessary for osteoclasts formation and function. Simultaneously, HFD and high cholesterol makes it more likely for the collar osteoblasts to undergo ferroptosis. The denatured matrix is prone to attract dendritic cells, whose activation could produce RANKL for osteoclasts in the pathology state. While RANK is activated, several pathways are involved to activate NFATc1 to fulfill bone absorption