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. 2022 Jan 8;20:28. doi: 10.1186/s12951-021-01208-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Effect of the 3D hydrogel/nanofiber composite scaffolds on collagen deposition in the wound beds. Masson trichrome staining images of wound tissues treated at A 7 days and B 11 days (green arrows indicate the edges of the wounds; blue areas indicate the collagen fibers). PCR gene quantitative analysis of C Collagen I, D Collagen III, E TGF-β expressed in different groups on 11 days. Values are expressed as mean ± standard deviation (SD) (n = 3) (*P < 0.05, **P < 0.01, ***P < 0.001)