Table 2.
Association of genotypes related to POI with lipid profile in target population divided into POI cases and healthy controls
| Polymorphisms | POI cases (N = 117) | Controls (N = 183) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| rs16991615 | AA | GA | GG | P | AA | GA | GG | P | |
| Serum total cholesterol (mg/dl) | 222.3 ± 41.4a | 195.8 ± 35.3b | 209.4 ± 29.5ab | 0.01 | 190.2 ± 33.8 | 191.2 ± 33.5 | 186.4 ± 32.7 | 0.64 | |
| Triglyceride (mg/dl) |
108.0 (78.0–181.0) |
112.0 (82.0–147.0) |
107.0 (89.0–156.0) |
0.96 |
98.5 (65.8–121.3) |
129.0 (87.0–159.0) |
108.0 (79.5–162.3) |
0.14 | |
| HDL (mg/dl) | 48.6 ± 7.7 | 45.9 ± 8.9 | 48.0 ± 10.5 | 0.44 |
45.0 (40.8–53.0) |
44.0 (35.0–53.0) |
43.0 (35.6–54.3) |
0.58 | |
| LDL (mg/dl) | 136.1 ± 37.8 | 120.3 ± 29.9 | 130.6 ± 34.1 | 0.15 | 116.7 ± 35.2 | 112.7 ± 34.0 | 107.1 ± 32.5 | 0.39 | |
| rs244715 | GG | AG | AA | P | GG | AG | AA | P |
|---|---|---|---|---|---|---|---|---|
| Serum total cholesterol (mg/dl) | 213.3 ± 44.4ab | 216.7 ± 35.5a | 198.8 ± 32.3b | 0.04 | 185.8 ± 25.8 | 182.9 ± 29.2 | 192.1 ± 35.0 | 0.21 |
| Triglyceride (mg/dl) |
140.5 (77.5–202.7) |
112.0 (85.0–179.0) |
108.0 (82.7–151.5) |
0.75 |
107.0 (84.0–231.3) |
122.0 (85.5–163.5) |
113.0 (77.0–149.5) |
0.55 |
| HDL (mg/dl) | 46.3 ± 8.6 | 47.8 ± 8.2 | 47.4 ± 10.5 | 0.88 |
43.5 (33.8–49.3) |
42.0 (36.3–55.7) |
44.0 (35.6–52.9) |
0.93 |
| LDL (mg/dl) |
126.8 (111.9–158.8) |
134.4 (115.9–146.5) |
124.1 (93.1–142.6) |
0.18 | 96.1 ± 36.4ab | 97.2 ± 34.3a | 118.2 ± 30.5b | < 0.001 |
| rs451417 | AA | CA | CC | P | AA | CA | CC | P |
|---|---|---|---|---|---|---|---|---|
| Serum total cholesterol (mg/dl) |
201.0 (191.0–236.0) |
207.5 (178.0–231.7) |
208.5 (181.2–223.2) |
0.71 |
194.5 (174.0–211.5) |
181.5 (164.5–201.5) |
192.0 (162.0–217.0) |
0.31 |
| Triglyceride (mg/dl) |
120.0 (82.0–185.0) |
111.5 (78.3–153.0) |
107.5 (84.5–151.5) |
0.51 |
106.0 (88.3–144.0) |
124.0 (77.3–166.5) |
115.0 (80.0–154.0) |
0.94 |
| HDL (mg/dl) | 47.5 ± 9.1 | 46.2 ± 9.0 | 48.4 ± 9.8 | 0.56 |
45.5 (39.3–54.4) |
43.5 (34.3–54.5) |
42.8 (36.6–52.1) |
0.78 |
| LDL (mg/dl) | 132.3 ± 38.3 | 122.0 ± 29.8 | 130.7 ± 33.9 | 0.39 | 117.4 ± 28.9 | 104.7 ± 34.1 | 113.9 ± 33.3 | 0.14 |
| rs1046089 | AA | GA | GG | P | AA | GA | GG | P |
|---|---|---|---|---|---|---|---|---|
| Serum total cholesterol (mg/dl) |
196.0 (177.0–225.0) |
207.0 (184.0–232.0) |
209.0 (186.5–224.5) |
0.76 | 177.1 ± 23.4 | 192.5 ± 33.1 | 188.0 ± 35.0 | 0.13 |
| Triglyceride (mg/dl) |
112.0 (79.0–214.0) |
112.0 (82.0–153.0) |
109.0 (84.0–154.5) |
0.87 |
112.0 (80.0–155.0) |
118.0 (84.0–162.5) |
117.0 (76.0–159.0) |
0.55 |
| HDL (mg/dl) | 50.4 ± 7.7 | 47.4 ± 9.4 | 46.6 ± 9.7 | 0.49 |
52.0 (40.0–58.0)a |
45.0 (34.0–55.0)ab |
43.0 (35.1–50.0)b |
0.03 |
| LDL (mg/dl) | 122.5 ± 40.1 | 127.2 ± 32.8 | 132.2 ± 34.7 | 0.65 |
75.5 (58.6–111.0)a |
108.0 (87.1–137.0)b |
122.5 (101.1–138.6)bc |
< 0.001 |
| rs7246479 | AA | TA | TT | P | AA | TA | TT | P |
|---|---|---|---|---|---|---|---|---|
| Serum total cholesterol (mg/dl) |
201.5 (196.3–233.5) |
200.5 (176.0–225.5) |
213.0 (200.0–234.0) |
0.12 | 178.6 ± 21.3 | 187.2 ± 31.8 | 191.3 ± 35.1 | 0.48 |
| Triglyceride (mg/dl) |
101.5 (73.3–167.0) |
108.0 (81.3–150.7) |
118.0 (94.0–186.0) |
0.29 |
145.0 (93.5–164.3) |
118.5 (84.7–152.3) |
107.0 (77.0–161.0) |
0.63 |
| HDL (mg/dl) | 48.7 ± 7.1 | 47.6 ± 9.2 | 46.8 ± 10.4 | 0.83 |
53.5 (41.5–57.7) |
44.0 (35.0–52.5) |
42.8 (36.0–53.1) |
0.26 |
| LDL (mg/dl) | 137.9 ± 31.2 | 123.8 ± 30.7 | 133.6 ± 39.8 | 0.23 | 82.6 ± 29.4a | 107.8 ± 33.9ab | 115.5 ± 32.0b | 0.02 |
| rs4806660 | CC | TC | TT | P | CC | TC | TT | P |
|---|---|---|---|---|---|---|---|---|
| Serum total cholesterol (mg/dl) | 200.6 ± 34.8ab | 217.0 ± 34.3a | 199.8 ± 35.9b | 0.04 | 161.4 ± 25.1 | 189.1 ± 33.2 | 190.6 ± 32.9 | 0.08 |
| Triglyceride (mg/dl) |
93.5 (73.3–168.0)ab |
122.0 (97.5–183.5)a |
100.0 (73.0–140.0)b |
0.02 |
133.0 (100.0–167.0) |
111.5 (80.7–160.5) |
117.0 (76.7–156.0) |
0.66 |
| HDL (mg/dl) | 53.5 ± 12.3a | 44.9 ± 8.0b | 48.7 ± 9.0ab | 0.01 |
46.0 (40.0–56.0) |
43.7 (35.5–54.3) |
43.2 (35.7–52.5) |
0.82 |
| LDL (mg/dl) | 112.2 ± 32.9 | 134.7 ± 34.9 | 125.6 ± 32.1 | 0.08 | 73.1 ± 26.1a | 104.3 ± 33.0b | 118.6 ± 31.4c | < 0.001 |
| rs10183486 | TT | CT | CC | P | TT | CT | CC | P |
|---|---|---|---|---|---|---|---|---|
| Serum total cholesterol (mg/dl) | 197.7 ± 27.7ab | 199.3 ± 34.6a | 220.1 ± 35.9b | 0.01 | 193.9 ± 35.3 | 192.4 ± 36.5 | 185.2 ± 29.5 | 0.32 |
| Triglyceride (mg/dl) |
97.5 (74.7–119.5) |
107.5 (80.7–150.7) |
122.0 (94.0–185.0) |
0.12 |
143.0 (91.0–180.5) |
111.0 (77.5–144.0) |
120.0 (82.5–164.5) |
0.23 |
| HDL (mg/dl) | 47.2 ± 6.4 | 47.7 ± 11.2 | 47.2 ± 7.5 | 0.95 |
35.5 (31.4–39.3)a |
44.0 (39.0–54.5)b |
43.5 (34.0–53.3)bc |
0.02 |
| LDL (mg/dl) | 118.9 ± 25.1ab | 119.5 ± 31.1a | 140.9 ± 35.5b | 0.003 | 120.5 ± 29.3 | 114.4 ± 34.3 | 106.1 ± 32.7 | 0.17 |
| rs2303369 | TT | CT | CC | P | TT | CT | CC | P |
|---|---|---|---|---|---|---|---|---|
| Serum total cholesterol (mg/dl) | 206.5 ± 29.7 | 213.6 ± 36.8 | 200.8 ± 36.5 | 0.23 | 181.9 ± 19.6 | 192.6 ± 32.8 | 185.9 ± 35.3 | 0.19 |
| Triglyceride (mg/dl) |
98.0 (69.0–129.0) |
117.0 (94.5–182.0) |
106.0 (77.5–152.0) |
0.05 |
106.0 (75.0–150.0) |
120.0 (84.5–162.3) |
117.0 (76.0–154.5) |
0.36 |
| HDL (mg/dl) | 52.0 ± 10.1a | 44.6 ± 8.5b | 48.9 ± 9.1ab | 0.01 |
56.5 (49.8–60.8)a |
44.5 (34.0–55.0)b |
42.8 (35.3–48.7)bc |
0.002 |
| LDL (mg/dl) |
117.6 (100.9–139.6) |
134.4 (116.3–149.0) |
123.6 (103.1–147.8) |
0.14 | 85.8 ± 27.6a | 109.7 ± 32.2b | 117.1 ± 33.2bc | 0.001 |
Statistically significant values are shown in bold
POI: Primary Ovarian Insufficiency; HDL: High-Density Lipoprotein; LDL: Low Density Lipoprotein; One-way analysis of variance (ANOVA) OR Kruskal–Wallis tests were used; Significant P value < 0.05