Table 3.
Investigation of the relationship between the risk of polymorphisms related to Primary Ovarian Insufficiency and dyslipidemia factors in the study population in a non-adjusted model
|
Polymorphisms Lipid profile abnormalities |
POI cases | Controls | ||||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| rs16991615 | GA/AA | GG/AA | GA/AA | GG/AA | ||||
| High LDL (mg/dl) | 0.65 (0.24, 1.74) | 0.39 | 1.15 (0.45,2.97) | 0.77 | 0.65 (0.23, 1.84) | 0.42 | 0.46 (0.16,1.30) | 0.14 |
| High Triglyceride (mg/dl) | 0.51 (0.17, 1.50) | 0.22 | 0.87 (0.32, 2.35) | 0.79 | 1.93 (0.51, 7.32) | 0.33 | 2.41 (0.64, 9.02) | 0.19 |
| Low HDL (mg/dl) | 1.43 (0.52, 3.89) | 0.48 | 1.08 (0.41, 2.80) | 0.87 | 0.96 (0.32, 2.85) | 0.94 | 0.88 (0.30, 2.59) | 0.82 |
| High total cholesterol (mg/dl) | 0.36 (0.12, 1.02) | 0.054 | 0.89 (0.32, 2.51) | 0.83 | 0.64 (0.23, 1.83) | 0.41 | 0.63 (0.22, 1.78) | 0.39 |
| rs244715 | AG/GG | AA/GG | AG/GG | AA/GG | ||||
|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 2.06 (0.57, 7.47) | 0.27 | 1.03 (0.29, 3.69) | 0.95 | 1.22 (0.13, 11.47) | 0.85 | 3.16 (0.35, 28.01) | 0.30 |
| High Triglyceride (mg/dl) | 0.42 (0.11, 1.54) | 0.19 | 0.38 (0.10, 1.38) | 0.14 | 1.12 (0.19, 6.66) | 0.89 | 0.66 (0.11, 3.83) | 0.64 |
| Low HDL (mg/dl) | 0.61 (0.16, 2.34) | 0.48 | 0.78 (0.21, 2.93) | 0.72 | 0.38 (0.04, 3.47) | 0.39 | 0.35 (0.04, 3.11) | 0.34 |
| High total cholesterol (mg/dl) | 1.86 (0.52, 6.94) | 0.35 | 0.76 (0.21, 2.72) | 0.68 | 0.71 (0.12, 4.26) | 0.71 | 1.31 (0.23, 7.47) | 0.75 |
| rs451417 | CA/AA | CC/AA | CA/AA | CC/AA | ||||
|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 1.23 (0.47, 3.26) | 0.66 | 1.80 (0.71, 4.52) | 0.21 | 0.53 (0.18, 1.55) | 0.25 | 1.19 (0.43, 3.28) | 0.73 |
| High Triglyceride (mg/dl) | 0.69 (0.25, 1.91) | 0.48 | 0.55 (0.21, 1.48) | 0.24 | 1.96 (0.59, 6.48) | 0.27 | 1.52 (0.46, 5.02) | 0.48 |
| Low HDL (mg/dl) | 1.27 (0.47, 3.42) | 0.62 | 0.94 (0.37, 2.35) | 0.89 | 0.82 (0.29, 2.30) | 0.71 | 1.19 (0.42, 3.33) | 0.73 |
| High total cholesterol (mg/dl) | 0.88 (0.33, 2.35) | 0.80 | 1.07 (0.42, 2.75) | 0.87 | 0.57 (0.20, 1.59) | 0.28 | 1.01 (0.37, 2.72) | 0.98 |
| rs1046089 | GA/AA | GG/AA | GA/AA | GG/AA | ||||
|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 2.58 (0.62, 10.62) | 0.18 | 3.50 (0.79, 15.34) | 0.09 | 4.82 (1.05, 21.98) | 0.04 | 6.83 (1.48, 31.46) | 0.01 |
| High Triglyceride (mg/dl) | 0.46 (0.12, 1.69) | 0.24 | 0.57 (0.14, 2.27) | 0.43 | 1.04 (0.38, 2.83) | 0.92 | 0.77 (0.27, 2.18) | 0.63 |
| Low HDL (mg/dl) | 1.68 (0.46, 6.10) | 0.42 | 2.21 (0.56, 8.67) | 0.25 | 1.76 (0.70, 4.44) | 0.22 | 3.21 (1.20, 8.53) | 0.02 |
| High total cholesterol (mg/dl) | 1.92 (0.53, 6.95) | 0.32 | 2.21 (0.56, 8.67) | 0.25 | 2.33 (0.79, 6.85) | 0.12 | 1.83 (0.60, 5.55) | 0.28 |
| rs7246479 | TA/AA | TT/AA | TA/AA | TT/AA | ||||
|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 0.46 (0.13, 1.61) | 0.22 | 1.36 (0.35, 5.24) | 0.64 | 2.86 (0.33, 24.54) | 0.33 | 3.93 (0.46, 33.38) | 0.21 |
| High Triglyceride (mg/dl) | 1.04 (0.25, 4.29) | 0.95 | 2.25 (0.51, 9.76) | 0.27 | 0.34 (0.07, 1.49) | 0.15 | 0.43 (0.10, 1.87) | 0.26 |
| Low HDL (mg/dl) | ||||||||
| High total cholesterol (mg/dl) | 0.53 (0.14, 1.93) | 0.34 | 1.68 (0.40, 7.09) | 0.47 | 1.44 (0.27, 7.63) | 0.66 | 1.85 (0.35, 9.71) | 0.46 |
| rs4806660 | TC/CC | TT/CC | TC/CC | TT/CC | ||||
|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 2.72 (0.72, 10.21) | 0.13 | 1.63 (0.43, 6.13) | 0.47 | – | – | – | – |
| High Triglyceride (mg/dl) | 1.87 (0.45, 7.76) | 0.38 | 0.97 (0.22, 4.18) | 0.97 | 0.61 (0.12, 2.96) | 0.54 | 0.45 (0.09, 2.19) | 0.32 |
| Low HDL (mg/dl) | 7.40 (1.75, 31.16) | 0.01 | 3.68 (0.88, 15.27) | 0.07 | 073 (0.13, 4.01) | 0.72 | 0.73 (0.13, 4.02) | 0.72 |
| High Total Cholesterol (mg/dl) | 2.14 (0.57, 7.92) | 0.25 | 0.63 (0.17, 2.26) | 0.48 | – | – | – | – |
| rs10183486 | CT/TT | CC/TT | CT/TT | CC/TT | ||||
|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 0.82 (0.23, 2.94) | 0.76 | 2.71 (0.74, 9.92) | 0.13 | 1.95 (0.38, 10.02) | 0.42 | 1.43 (0.27, 7.33) | 0.66 |
| High Triglyceride (mg/dl) | 1.75 (0.34, 8.98) | 0.50 | 3.39 (0.66, 17.25) | 0.14 | 0.33 (0.08, 1.37) | 0.12 | 0.65 (0.16, 2.61) | 0.55 |
| Low HDL (mg/dl) | 0.62 (0.16, 2.32) | 0.48 | 0.80 (0.21, 3.06) | 0.75 | 0.23 (0.02, 1.98) | 0.18 | 0.20 (0.02, 1.72) | 0.14 |
| High Total Cholesterol (mg/dl) | 1.50 (0.42, 5.34) | 0.52 | 4.58 (1.21, 17.35) | 0.02 | 1.30 (0.30, 5.60) | 0.72 | 0.90 (0.21, 3.87) | 0.89 |
| rs2303369 | CT/TT | CC/TT | CT/TT | CC/TT | ||||
|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 2.41 (0.82, 7.11) | 0.11 | 1.34 (0.43, 4.10) | 0.61 | 6.77 (0.85, 53.83) | 0.07 | 9.06 (1.13, 72.25) | 0.03 |
| High Triglyceride (mg/dl) | 3.23 (0.83, 12.49) | 0.08 | 2.20 (0.54, 8.99) | 0.26 | 1.42 (0.42, 4.80) | 0.56 | 1.05 (0.30, 3.64) | 0.93 |
| Low HDL (mg/dl) | 6.03 (1.92, 18.94) | 0.002 | 2.51 (0.79, 7.89) | 0.11 | 4.94 (1.47, 16.55) | 0.01 | 9.83 (2.82, 34.27) | < 0.001 |
| High Total Cholesterol (mg/dl) | 0.75 (0.23, 2.44) | 0.64 | 0.30 (0.09, 1.01) | 0.05 | 2.88 (0.76, 10.86) | 0.11 | 2.08 (0.54, 7.98) | 0.28 |
Binary logistic regression models were performed; POI: Primary Ovarian Insufficiency; LDL: Low-Density Lipoprotein; HDL: High-Density Lipoprotein; High LDL > 130 and Normal LDL < 130; High Triglyceride > 150 and Normal Triglyceride < 150; Low HDL < 40 (Male) or < 50 (Female) and Normal HDL > 40 (Male) or > 50 (Female), High Total Cholesterol > 200 and Normal Total Cholesterol < 200; Normal groups of all lipid profile measures were considered as references; The common genotypes of each studied variants were considered as references; Significant P-value < 0.05