Table 4.
Investigation of the relationship between the risk of polymorphisms related to Primary Ovarian Insufficiency and dyslipidemia factors in the study population in an adjusted model for age and physical activity level
|
Polymorphisms Lipid profile abnormalities |
POI cases | Control | ||||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| rs16991615 | GA/AA | GG/AA | GA/AA | GG/AA | ||||
| High LDL (mg/dl) | 0.63 (0.23, 1.72) | 0.36 | 1.21 (0.46, 3.17) | 0.69 | 0.67 (0.22, 2.04) | 0.48 | 0.37 (0.12, 1.15) | 0.08 |
| High Triglyceride (mg/dl) | 0.45 (0.15, 1.38) | 0.16 | 0.84 (0.30, 2.33) | 0.74 | 1.38 (0.34, 5.53) | 0.64 | 1.69 (0.43, 6.61) | 0.45 |
| Low HDL (mg/dl) | 1.37 (0.50, 3.76) | 0.54 | 1.05 (0.40, 2.76) | 0.91 | 0.63 (0.19, 2.05) | 0.45 | 0.59 (0.18, 1.89) | 0.38 |
| High Total Cholesterol (mg/dl) | 0.34 (0.12, 0.99) | 0.04 | 0.91 (0.32, 2.57) | 0.86 | 0.67 (0.22, 2.02) | 0.48 | 0.55 (0.18, 1.65) | 0.29 |
| rs244715 | AG/GG | AA/GG | AG/GG | AA/GG | |||||
|---|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 2.13 (0.58, 7.82) | 0.25 | 1.02 (0.28, 3.69) | 0.96 | 1.18 (0.12, 11.32) | 0.88 | 3.11 (0.34, 27.94) | 0.31 | |
| High Triglyceride (mg/dl) | 0.39 (0.10, 1.48) | 0.17 | 0.36 (0.09, 1.36) | 0.13 | 1.44 (0.23, 8.86) | 0.69 | 0.74 (0.12, 4.44) | 0.75 | |
| Low HDL (mg/dl) | 0.60 (0.15, 2.30) | 0.46 | 0.78 (0.21, 2.96) | 0.72 | 0.48 (0.05, 4.45) | 0.52 | 0.39 (0.04, 3.53) | 0.41 | |
| High Total Cholesterol (mg/dl) | 1.88 (0.50, 7.04) | 0.35 | 0.76 (0.21, 2.72) | 0.68 | 0.68 (0.11, 4.21) | 0.68 | 1.28 (0.22, 7.38) | 0.78 | |
| rs451417 | CA/AA | CC/AA | CA/AA | CC/AA | |||||
|---|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 1.27 (0.47, 3.42) | 0.63 | 1.80 (0.71, 4.58) | 0.21 | 0.52 (0.17, 1.55) | 0.24 | 0.99 (0.35, 2.83) | 0.99 | |
| High Triglyceride (mg/dl) | 0.57 (0.19, 1.63) | 0.29 | 0.51 (0.18, 1.39) | 0.19 | 1.84 (0.54, 6.30) | 0.32 | 1.34 (0.39, 4.60) | 0.64 | |
| Low HDL (mg/dl) | 1.18 (0.43, 3.22) | 0.74 | 0.91 (0.36, 2.32) | 0.85 | 0.72 (0.24, 2.10) | 0.55 | 1.09 (0.37, 3.18) | 0.87 | |
| High Total Cholesterol (mg/dl) | 0.86 (0.31, 2.35) | 0.77 | 1.06 (0.41, 2.73) | 0.89 | 0.56 (0.19, 1.60) | 0.28 | 0.84 (0.30, 2.35) | 0.75 | |
| rs1046089 | GA/AA | GG/AA | GA/AA | GG/AA | |||||
|---|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 2.52 (0.61, 10.45) | 0.20 | 3.62 (0.82, 16.09) | 0.09 | 3.64 (0.75,17.59) | 0.10 | 5.89 (1.22, 28.34) | 0.02 | |
| High Triglyceride (mg/dl) | 0.45 (0.11, 1.71) | 0.24 | 0.59 (0.14, 2.42) | 0.47 | 0.64 (0.21, 1.92) | 0.42 | 0.46 (0.15, 1.45) | 0.18 | |
| Low HDL (mg/dl) | 1.72 (0.47, 6.25) | 0.41 | 2.31 (0.58, 9.15) | 0.23 | 1.33 (0.48, 3.67) | 0.58 | 2.42 (0.85, 6.84) | 0.09 | |
| High Total Cholesterol (mg/dl) | 1.90 (0.52, 6.92) | 0.33 | 2.26 (0.57, 8.93) | 0.24 | 1.75 (0.55, 5.53) | 0.33 | 1.53 (0.48, 4.88) | 0.47 | |
| rs7246479 | TA/AA | TT/AA | TA/AA | TT/AA | |||||
|---|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 0.45 (0.12, 1.62) | 0.22 | 1.47 (0.37, 5.78) | 0.58 | 1.97 (0.22, 17.75) | 0.54 | 2.42 (0.26, 22.31) | 0.43 | |
| High Triglyceride (mg/dl) | 0.96 (0.22, 4.12) | 0.96 | 2.27 (0.50, 10.30) | 0.28 | 0.15 (0.02, 0.88) | 0.03 | 0.15 (0.02, 0.95) | 0.04 | |
| Low HDL (mg/dl) | 1.37 (0.39, 4.77) | 0.61 | 1.65 (0.43, 6.30) | 0.45 | 4.27 (0.75, 24.30) | 0.10 | 5.79 (0.98, 33.99) | 0.05 | |
| High Total Cholesterol (mg/dl) | 0.51 (0.14, 1.91) | 0.32 | 1.74 (0.40, 7.41) | 0.45 | 0.99 (0.17, 5.59) | 0.99 | 1.14 (0.19, 6.62) | 0.88 | |
| rs4806660 | TC/CC | TT/CC | TC/CC | TT/CC | |||||
|---|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 2.64 (0.68, 10.16) | 0.15 | 1.56 0.40, 6.14) | 0.52 | – | – | – | – | |
| High Triglyceride (mg/dl) | 1.55 (0.35, 6.76) | 0.55 | 0.70 (0.15, 3.24) | 0.65 | 0.44 (0.08, 2.44) | 0.35 | 0.32 (0.06, 1.77) | 0.19 | |
| Low HDL (mg/dl) | 6.91 (1.61, 29.50) | 0.01 | 3.32 (0.78, 14.17) | 0.10 | 0.62 (0.10, 3.66) | 0.60 | 0.60 (0.10, 3.50) | 0.57 | |
| High Total Cholesterol (mg/dl) | 1.95 (0.51, 7.45) | 0.32 | 0.55 (0.14, 2.11) | 0.39 | – | – | – | – | |
| rs10183486 | CT/TT | CC/TT | CT/TT | CC/TT | |||||
|---|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 0.68 (0.18, 2.54) | 0.57 | 2.36 (0.63, 8.86) | 0.20 | 2.01 (0.38, 10.70) | 0.41 | 1.29 (0.24, 6.85) | 0.76 | |
| High Triglyceride (mg/dl) | 1.68 (0.31, 8.92) | 0.54 | 3.51 (0.67, 18.40) | 0.13 | 0.35 (0.08, 1.49) | 0.15 | 0.66 (0.16, 2.73) | 0.57 | |
| Low HDL (mg/dl) | 0.62 (0.16, 2.38) | 0.49 | 0.82 (0.21, 3.20) | 0.77 | 0.26 (0.3, 2.22) | 0.22 | 0.21 (0.02, 1.84) | 0.16 | |
| High Total Cholesterol (mg/dl) | 1.43 (0.39, 5.21) | 0.58 | 4.43 (1.14, 17.16) | 0.03 | 1.32 (0.29, 5.83) | 0.71 | 0.81 (0.18, 3.57) | 0.78 | |
| rs2303369 | CT/TT | CC/TT | CT/TT | CC/TT | |||||
|---|---|---|---|---|---|---|---|---|---|
| High LDL (mg/dl) | 2.21 (0.74, 6.60) | 0.15 | 1.24 (0.39, 3.87) | 0.71 | 4.77 (0.57, 39.79) | 0.15 | 7.48 (0.90, 61.75) | 0.06 | |
| High Triglyceride (mg/dl) | 3.22 (0.81, 12.85) | 0.09 | 1.95 (0.46, 8.17) | 0.36 | 0.89 (0.24, 3.35) | 0.87 | 0.65 (0.17, 2.49) | 0.53 | |
| Low HDL (mg/dl) | 6.19 (1.93, 19.88) | 0.002 | 2.39 (0.74, 7.66) | 0.14 | 4.03 (1.12, 14.48) | 0.03 | 7.97 (2.19, 28.96) | 0.002 | |
| High Total Cholesterol (mg/dl) | 0.68 (0.20, 2.27) | 0.54 | 0.27 (0.07, 0.93) | 0.03 | 2.12 (0.52, 8.55) | 0.28 | 1.72 (0.42, 6.93) | 0.44 | |
Statistically significant values are shown in bold
Binary logistic regression models were performed; POI: Primary Ovarian Insufficiency; LDL: Low-Density Lipoprotein; HDL: High-Density Lipoprotein; High LDL > 130 and Normal LDL < 130; High Triglyceride > 150 and Normal Triglyceride < 150; Low HDL < 40 (Male) or < 50 (Female) and Normal HDL > 40 (Male) or > 50 (Female), High Total Cholesterol > 200 and Normal Total Cholesterol < 200; Normal groups of all lipid profile measures were considered as references; The common genotypes of each studied variants were considered as references; Adjusted with Age & Physical Activity Level; Significant P-value < 0.05