Table 5.

The content of MDA and activities of SOD and GSH-Px in the serum of mice at 10 months of age.

Group	n	MDA (nmol/mgprot)	SOD (U/mg prot)	GSH-Px (kU/L)
WT	10	1.72±0.91	88.9±2.72	720±3.86
APP/PS1	10	8.06±0.76**	58.3±4.39**	506±19.3**
APP/PS1+PUN-282987	10	2.74±0.99##	81.1±1.94*,##	688±16.3*,##

WT – wild-type; APP/PS1 – amyloid precursor protein/presenilin 1; pr – protein; SOD – superoxide dismutase; GSH-Px – glutathione peroxidase. The values presented are means±standard deviation.

^*P<0.05 or

^**P<0.01 vs control (WT);

^#P<0.05 or

^##P<0.01 vs APP/PS1, as determined by analysis of variance (ANOVA), followed by the Tukey HSD test.