Table 3.
Characteristics of patients with drug hypersensitivity reactions.
| n (%) | |
|---|---|
| Total | 175 (13.7) |
| Sex | |
| Female | 99 (57) |
| Male | 76 (43) |
| Atopy | 46 (26) |
| Comorbidity | 149 (85) |
| Immediate type | 163 (93.1) |
| Urticaria, without angioedema | 87 (53.4) |
| Antibiotics1 | 27 (31) |
| NSAIDs | 25 (28.7) |
| Cardiovascular drugs | 8 (9.3) |
| Chemotherapeutics | 8 (9.3) |
| Allopurinol | 5 (5.7) |
| Local anesthetics | 4 (4.6) |
| Contrast agents | 3 (3.4) |
| Others | 7 (8.0) |
| Anaphylaxis | 45 (27.6) |
| NSAIDs | 21 (46.7) |
| Antibiotics2 | 19 (42.2) |
| Others3 | 5 (11.1) |
| Urticaria, with angioedema | 20 (12.3) |
| NSAIDs | 13 (65) |
| Antibiotics1 | 5 (25) |
| Others | 2 (10) |
| Angioedema, without urticaria | 11 (6.7) |
| NSAIDs | 8 (72.7) |
| Others | 3 (27.3) |
| Delayed type | 12 (6.9) |
| SJS/TEN | 6 (50) |
| Allopurinol | 2 (33.2) |
| Carbamazepine | 2 (33.2) |
| NSAIDs | 1 (16.6) |
| Antibiotics | 1 (16.6) |
| DRESS | 3 (25) |
| Allopurinol | 2 (66.7) |
| Carbamazepine | 1 (33.3) |
| Allergic contact dermatitis | 2 (16.7) |
| NSAIDs | 2 (100) |
| FDE | 1 (8.3) |
| NSAIDs | 1 (100) |
NSAIDs: Nonsteroidal antiinflammatory drugs, SJS: Stevens–Johnson syndrome, TEN: Toxic epidermal necrolysis, DRESS: Drug reaction with eosinophilia and systemic syndrome, FDE: Fixed drug eruption.1 Beta lactams (54%), quinolones (25%).2 Beta lactams (84.2%).3 Proton pump inhibitors (n = 2), local anesthetics (n = 1), vitamin B12 (n = 1), ranitidine (n = 1).