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. Author manuscript; available in PMC: 2022 Jan 8.
Published in final edited form as: Mol Carcinog. 2019 Apr 21;58(8):1438–1449. doi: 10.1002/mc.23026

Figure 2. Effect of RLIP-targeting treatments on tissue morphology in DMBA-administered SENCAR mice.

Figure 2

Tissue sections from DMBA-administered female SENCAR mice that received a control treatment (corn oil, CAS, or PIS) or an experimental treatment (2HF, RAS, Rab, or a combination of 2HF+RAS+Rab) were used for H&E staining. Hemorrhagic areas involving the liver, duodenum, spleen, kidney, bone marrow, mammary gland, brain, lung, and heart tissues were observed in the corn oil-, CAS-, and PIS-treated mice whereas tissues from 2HF-, RAS-, Rab-, and combination-treated mice were histologically normal. Representative images at x400 magnification are shown. 2HF, 2'-hydroxyflavanone-treated; CAS, scrambled antisense-treated; RAS, RLIP antisense-treated; PIS, preimmune serum-treated; Rab, RLIP antibody-treated.