Table 1.
Regulation of blood chemistry parameters in control and DMBA-administered mice, following 2HF and RLIP antisense treatment.
| Blood Profile* | Corn oil (control) |
DMBA | 2HF | DMBA + 2HF |
Scrambled antisense |
RLIP antisense |
DMBA + RLIP antisense |
|---|---|---|---|---|---|---|---|
| RBCs (106/μL) | 8.8 ± 1.8 | 7.2 ± 1.7 | 8.9 ± 2.4 | 8.3 ± 2.1 | 8.5 ± 1.7 | 8.1 ± 1.9 | 7.9 ± 2.2 |
| WBCs (103/μL) | 7.5 ± 1.7 | 10.4 ± 2.4** | 7.3 ± 1.5 | 8.1 ± 2.7 | 8.2 ± 2.1 | 7.8 ± 1.6 | 8.5 ± 2.4 |
| Platelets (103/μL) | 722 ± 129 | 888 ± 154 | 645 ± 127 | 752 ± 129 | 704 ± 132 | 618 ± 112 | 686 ± 138 |
| Hemoglobin (g/dL) | 12.9 ± 1.4 | 10.1 ± 1.8 | 12.5 ± 1.8 | 12.1 ± 2.1 | 12.4 ± 2.1 | 11.3 ± 1.7 | 11.1 ± 1.9 |
| Hematocrit (%) | 38.6 ± 8.7 | 31.2 ± 5.9 | 41.1 ± 3.6 | 40.3 ± 7.2 | 40.2 ± 6.7 | 37.7 ± 4.4 | 36.8 ± 4.7 |
| MCHC (g/dL) | 32.8 ± 3.9 | 30.4 ± 3.1 | 32.1 ± 4.3 | 32.2 ± 2.7 | 32.9 ± 4.2 | 31.6 ± 3.2 | 31.1 ± 2.8 |
| Neutrophil (%) | 21.9 ± 6.1 | 33.7 ± 7.9** | 23.8 ± 4.4 | 24.1 ± 5.2 | 22.8 ± 3.9 | 23.7 ± 3.3 | 23.9 ± 5.3 |
*
n = 3 mice/group;
**
Represents significant difference from the control (p < 0.03)