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. Author manuscript; available in PMC: 2022 Jan 8.
Published in final edited form as: Annu Rev Microbiol. 2018 Jun 15;72:185–207. doi: 10.1146/annurev-micro-090817-062329

Figure 3.

Figure 3.

The context specific action of PTC inhibitors chloramphenicol (CHL) and linezolid (LZD). (a) The chemical structures of CHL and LZD. (b) The binding site of CHL and LZD overlaps with that of the aminoacyl moiety of the A site aa-tRNA. (c) RiboSeq analysis shows that CHL (and LZD) causes redistribution of ribosomes on mRNA (51). In the presence of either one of the inhibitors, ribosomes are preferentially arrested at the codons that immediately follow Ala codons. (d) Cartoon representation of the preferred target of CHL (or LZD), a ribosome carrying a nascent peptide whose penultimate residue is an alanine.