Figure 3. Tissue distribution of R903/78 virus following multiple oral administrations in mice.

Balb/C mice were dosed with multiple oral deliveries of 1.7x10⁶ IU of IBDV on days 0, 3, 7, 13, and 20 (indicated with arrows). Necropsy was performed on days 1, 4, 8, 14, and 21. Tissue RNA was quantified by quantitative real-time RT-PCR. The transduction efficiency is expressed as IBDV copy numbers per mg of tissue. Each bar represents the arithmetic mean of four independent experiments, except D21 where 1 mouse died. Error bars indicate the standard error deviation (±SD; n = 4; n = 3 for D21)

Reproduced with slight modification from Hornyak et al., J Gene Med 2015, 17, 116 [15] with permission from John Wiley & Sons, Ltd. (License Number: 5176880126861)