Table 1.
Overall demographics of all centers including total and period-specific patient demographics.
| PwNID | Controls | p-value | |
| Total participants, n (%) | 1134 (55.9) | 868 (44.1) | |
| P1 | 423 | 404 | |
| P2 | 88 | 38 | |
| P3 | 623 | 426 | |
| MS diagnosis, n (%) | 1076 (94.9) | – | – |
| P1 | 402/423 (95) | ||
| P2 | 85/88 (97) | ||
| P3 | 589/623 (95) | ||
| Female gender, n (%) | 879 (77.5) | 593 (68.3) | p-value = 0.9 |
| P1 | 333/423 (79) | 326/404 (80) | |
| P2 | 68/88 (77) | 28/38 (74) | |
| P3 | 478/623 (77) | 342/426 (80) | |
| Age, mean (sd), total and cross-sectionally | 50.4 (12.8) | 46.2 (15.0) | p-value = 0.2 |
| P1 | 48.1 (12.5) | 41.6 (9.6) | |
| P2 | 47.2 (13.2) | 50.6 (16.9) | |
| P3 | 52.1 (12.5) | 43.0 (11.4) | |
| Race, Caucasian (%) total and cross-sectionally | 1022 (90.1) | 823 (94.8) | p-value = 0.9 |
| P1 | 380/423 (89) | 386/404 (96) | |
| P2 | 71/88 (81) | 33/38 (87) | |
| P3 | 571/623 (92) | 404/426 (95) | |
| Disease duration, years (sd), total and cross-sectionally | 12.8 (10.3) | _ | |
| P1 | 11.8 (9.5) | ||
| P2 | 9.2 (8.2) | ||
| P3 | 13.9 (10.4) | ||
| CCI, total and cross-sectionally, mean (sd) | 1.04 (1.3) | 0.96 (1.5) | p-value = 0.002 |
| P1 | 1.0 (1.2) | 0.8 (1.3) | |
| P2 | 1.1 (1.4) | 1.6 (1.9) | |
| P3 | 1.0 (1.4) | 1.1 (1.4) | |
| Loneliness Composite Index, mean (sd), total and cross-sectionally | 40 (11.7) | 39.3 (10.1) | p-value = 0.1 |
| P1 | 40.3 (11.5) | 38.8 (9.5) | |
| P2 | 40.2 (10.5) | 42.6 (10.9) | |
| P3 | 39.7 (11.6) | 38.7 (9.7) | |
| PROMIS Depression T-score mean (sd), total and cross-sectionally | 51.8 (8.5) | 50.9 (7.8) | p-value = 0.002 |
| P1 | 52.6 (8.1) | 51.2 (7.3) | |
| P2 | 53.1 (8.2) | 50.6 (8.0) | |
| P3 | 51.2 (8.4) | 51.0 (7.5) | |
| PROMIS Physical Function T-score mean (sd), total and cross-sectionally | 45.3 (10.9) | 55.7 (9.3) | p-value < 0.001 |
| P1 | 47.0 (10.8) | 58.8 (7.9) | |
| P2 | 48.0 (10.9) | 52.9 (10.0) | |
| P3 | 45.1 (10.9) | 56.8 (9.1) |
Periods are defined as first peak (period 1, P1), trough (P2), and second peak (P3) of the pandemic. PwNID, patients with inflammatory neurologic disease; CCI, Charlson Comorbidity Index.