Table 3.

Linear regression models of outcomes.

Dependent Factor	Population	Variables	Coefficients	p-value	Adjusted R-squared
PROMIS Depression	PwNID and controls	Older age Male gender No neuroinflammatory disease Lack of DMT use Higher loneliness composite index score	−4.3 −2.1 −6.0 5.3 12.9	< 0.001	0.2902
PROMIS Physical Function	PwNID and controls	Older age No neuroinflammatory disease Higher CCI	−6.3 18.8 −6.2	< 0.001	0.3585

Disease status indicates PwNID vs. controls. DMT status, disease modifying therapy; PwNID, person with neurologic inflammatory disease; CCI, Charlson Comorbidity Index.