Table 3.

Univariate and multivariable analyses

	Univariate analyses			Multivariable analyses
	sHR	95% CI	P-value	sHR	95% CI	P-value
Primary endpoint
MF presencea	12.3	1.74–1563	0.005	10.3	1.44–1305	0.013
TF2SD mass, per g	1.04	1.03–1.06	<0.001	1.04	1.03–10.6	<0.001
GZF3SD mass, per g	1.52	1.37–1.70	<0.001	1.48	1.32–1.67	<0.001
LVEF, per %	0.95	0.92–0.98	<0.001	0.95	0.92–0.98	0.003
Total mortality
MF presence	1.35	0.89–2.04	0.161	1.19	0.78–1.81	0.412
TF2SD mass, per g	1.01	1.00–1.01	0.108	1.01	1.00–1.02	0.060
GZF3SD mass, per g	1.07	1.02–1.03	0.006	1.08	1.02–1.14	0.007
LVEF, per %	0.97	0.96–0.98	<0.001	0.98	0.97–0.99	<0.001

Results from competing risks analyses with respect to the primary are expressed in terms of subdistribution hazard ratios (sHRs) and 95% confidence intervals (95% CIs). Results for total mortality were derived from Cox proportional hazards models, without correction for competing risks. Detailed results of the multivariable models are shown in Supplementary material online, Tables S2 and S3.

GZF_3SD, greyzone fibrosis using the 3SD method; LVEF, left ventricular ejection fraction; MF, myocardial fibrosis; TF_2SD, total fibrosis using the 2 SD method.

^aFrom Firth’s penalized likelihood method.