TABLE 2.
Summary of tacrolimus PK parameters (n = 24)
| Variable | Mean | SD | CV% | Median | Range, min–max |
|---|---|---|---|---|---|
| Cmax, µg/L | 12.32 | 3.67 | 29.76 | 11.64 | 6.95–22.07 |
| Tmax, h | 5.15 | 2.24 | 43.59 | 5.00 | 2.00–8.00 |
| AUC0–24, µg*h/L | 192.29 | 43.98 | 22.87 | 191.88 | 138.78–305.75 |
| Dose, mg | 4.53 | 5.15 | 113.69 | 2.73 | 0.75–25.50 |
| C0, µg/L | 5.79 | 1.65 | 28.41 | 5.33 | 3.10–9.49 |
| C0.5, µg/L | 5.93 | 1.36 | 22.85 | 5.76 | 4.27–8.89 |
| C1, µg/L | 6.81 | 1.94 | 28.50 | 6.51 | 4.02–10.64 |
| C1.5, µg/L | 7.51 | 2.79 | 37.08 | 6.90 | 4.06–15.49 |
| C2, µg/L | 8.27 | 3.31 | 40.01 | 7.44 | 4.11–16.23 |
| C2.5, µg/L | 9.07 | 3.81 | 42.05 | 8.03 | 4.68–22.07 |
| C3, µg/L | 9.78 | 3.61 | 36.91 | 9.03 | 4.85–18.82 |
| C4, µg/L | 10.24 | 3.66 | 35.73 | 9.51 | 5.94–18.08 |
| C6, µg/L | 10.65 | 2.97 | 27.87 | 10.73 | 6.02–16.51 |
| C8, µg/L | 9.74 | 2.54 | 26.08 | 9.37 | 6.00–15.04 |
| C10, µg/L | 8.85 | 2.29 | 25.92 | 8.53 | 5.68–15.44 |
| C12, µg/L | 8.09 | 2.07 | 25.56 | 7.71 | 5.54–13.48 |
| C24, µg/L | 5.71 | 1.40 | 24.50 | 5.32 | 3.60–9.30 |
Abbreviations: AUC0–24, area under the time‐concentration curve in a 24 h period; C0 to C24, the concentrations at 0 to 24 h; Cmax, maximum concentration; CV%, coefficient of variation; Tmax, time for reaching maximum concentration.