Table 3.
Effect of exercise intervention on the percent change (95% CI) in plasma circulating cell-free mitochondrial DNA per month
| Percent Change (95% CI) | P Value | Percent Change (95% CI)* | P Value | Percent Change (95% CI)† | P Value | |
|---|---|---|---|---|---|---|
| Overall (n = 99) | ||||||
| Usual activity | Reference | Reference | Reference | |||
| Aerobic exercise | 15.8 (2.0, 31.4) | 0.024 | 15.7 (1.9, 31.3) | 0.024 | 16.1 (2.0, 32.1) | 0.024 |
| Usual diet (n = 44) | ||||||
| Usual activity | Reference | Reference | Reference | |||
| Aerobic exercise | 1.3 (−15.9, 22.2) | 0.888 | 1.4 (−15.8, 22.1) | 0.885 | 2.0 (−15.7, 23.3) | 0.842 |
| Caloric restriction (n = 55) | ||||||
| Usual activity | Reference | Reference | Reference | |||
| Aerobic exercise | 29.3 (9.2, 53.1) | 0.003 | 29.1 (9.0, 52.8) | 0.003 | 29.5 (9.0, 54.0) | 0.003 |
| P value for interaction: 0.057‡ |
*Adjusted for age, race, and sex.
†Adjusted for age, race, sex, systolic blood pressure, body mass index, diabetes, and estimated glomerular filtration rate.
‡P value for interaction comes from a model with a three-way interaction between aerobic exercise, caloric restriction, and time. CI, confidence interval; n, number of participants.