Table 6.
Association between circulating cell-free mitochondrial DNA with markers of inflammation and oxidative stress per month
| Estimate (95% Confidence Interval) | P Value | |
|---|---|---|
| Overall | ||
| IL-6 | 0.998 (0.964, 1.034) | 0.924 |
| IL-8 | 1.001 (0.993, 1.008) | 0.860 |
| IL-10 | 1.024 (0.984, 1.065) | 0.243 |
| TNF-α | 0.999 (0.996, 1.003) | 0.682 |
| F2-isoprostanes | 0.998 (0.994, 1.003) | 0.491 |
| Isofurans | 1.002 (0.998, 1.006) | 0.333 |
| Aerobic exercise | ||
| IL-6 | 0.980 (0.934, 1.029) | 0.419 |
| IL-8 | 0.998 (0.991, 1.006) | 0.693 |
| IL-10 | 1.010 (0.958, 1.064) | 0.722 |
| TNF-α | 0.999 (0.994, 1.004) | 0.690 |
| F2-isoprostanes | 0.999 (0.994, 1.004) | 0.632 |
| Isofurans | 1.003 (0.998, 1.009) | 0.268 |
| Usual activity | ||
| IL-6 | 1.039 (0.985, 1.110) | 0.159 |
| IL-8 | 1.007 (0.991, 1.022) | 0.400 |
| IL-10 | 1.064 (1.000, 1.132) | 0.050 |
| TNF-α | 1.001 (0.996, 1.006) | 0.677 |
| F2-isoprostanes | 1.000 (0.993, 1.008) | 0.896 |
| Isofurans | 1.001 (0.995, 1.007) | 0.725 |
Note that all inflammation markers and oxidative stress markers were natural log transformed; circulating cell-free mitochondrial DNA was natural log transformed, and the slope was calculated using baseline, month 2, and month 4 values. IL, interleukin; TNF, tumor necrosis factor.