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. 2021 Dec 1;322(1):G117–G133. doi: 10.1152/ajpgi.00274.2021

Figure 3.

Figure 3.

Tissue total bile acid pool, relative bile acid species, estimate of hydrophobicity of bile acid pool, oxysterol content, and relative abundance in liver tissue. A: total bile acid content of liver and gallbladder contents, small intestine tissue, and luminal contents and total (liver and gallbladder contents, small intestinal tissue and luminal contents, and luminal contents of proximal colon) tissue bile acid pool in preterm (P) and term (T) pigs at birth and day 3 (Preterm-Birth, n = 16, Preterm-Day 3, n = 17, Term-Birth, n = 10, Term-Day 3, n = 13) represented by means ± SE. B: proportion of bile acid species, HDCA (hyodeoxycholic), HCA (hyocholic acid), CDCA (chenodeoxycholic acid), CA (cholic acid), and other (lithocholic acid and ursodeoxycholic acid) in livers of preterm (P) and term (T) piglets at birth and day 3 (Preterm-Birth, n = 9, Preterm-Day 3, n = 9, Term-Birth, n = 6, Term-Day 3, n = 8). C: estimate of relative hepatic bile acid pool hydrophobicity in liver tissue of preterm (P) and term (T) pigs at birth and day 3 (Preterm-Birth, n = 9, Preterm-Day 3, n = 9, Term-Birth, n = 6, Term-Day 3, n = 8). D–G: concentration (nmol/g liver tissue) of 25-OH-cholesterol (D), 27-OH-cholesterol (E), 7α-25-dihydroxy-cholestrol (F), 7α-OH-cholesten-3-one (C4) (G) in preterm (P) and term (T) pigs at birth and day 3. H: ratio of 25-OH-cholesterol and 27-OH-cholesterol to 7α-OH-cholesten-3-one (C4) in liver tissue. Preterm-Birth, n = 9, Preterm-Day 3, n = 9, Term-Birth, n = 6, Term-Day 3, n = 5. Data are shown as means ± SE. *P (GA × Day) < 0.05), ***P (GA × Day) < 0.001, ****P (GA × Day) < 0.0001. BW, body weight.