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. 2021 Dec 1;322(1):G117–G133. doi: 10.1152/ajpgi.00274.2021

Table 2.

Hepatic bile acid profile

Preterm Birth Term Birth Preterm Day 3 Term Day 3 P
GA Day GA × Day
CA BDL BDL 0.635 ± 0.022 0.075 ± 0.001 n/a n/a n/a
CDCA 0.194 ± 0.030 0.062 ± 0.001 2.055 ± 0.113 0.151 ± 0.020 0.150 0.120 0.208
HCA 0.085 ± 0.001 BDL 2.550 ± 0.130 0.458 ± 0.130 0.256 0.069 0.256
HDCA 0.392 ± 0.070 0.120 ± 0.030 3.380 ± 0.182 1.996 ± 0.800 0.564 0.043 0.646
DCA BDL BDL BDL BDL n/a n/a n/a
LCA 0.007 ± 0.001 BDL BDL BDL n/a n/a n/a
UDCA BDL BDL BDL 1.076 ± 0.290 n/a n/a n/a
Total UN-CONJ 0.666 ± 0.095 0.181 ± 0.035 8.054 ± 4.193 2.884 ± 1.065 0.298 0.059 0.394
G-CA 8.56 ± 1.39 6.80 ± 1.01 5.32 ± 0.45 3.93 ± 1.24 0.142 0.014 0.878
G-CDCA 20.53 ± 4.06 19.99 ± 3.52 29.31 ± 0.22 35.91 ± 6.24 0.373 0.015 0.447
G-HCA 33.82 ± 7.39 41.58 ± 6.13 26.440 ± 2.01 47.115 ± 1.09 0.074 0.821 0.422
G-DHCA 18.93 ± 3.95 32.541 ± 5.55 18.460 ± 2.95a 42.547 ± 3.82b <0.001 0.348 0.233
G-DCA BDL BDL BDL BDL n/a n/a n/a
G-LCA 0.127a ± 0.001 0.184 ± 0.002b 0.122 ± 0.001 0.150 ± 0.010 <0.001 0.075 0.151
G-UCDA 0.176 ± 0.030 0.350 ± 0.004 0.185 ± 0.030 0.272 ± 0.080 0.029 0.288 0.176
Total G-CONJ 85.65 ± 17.70 101.45 ± 9.87 79.80 ± 6.30 129.85 ± 12.02 0.040 0.566 0.305
T-CA 3.44 ± 0.65 1.83 ± 0.24 1.75 ± 0.26 1.19 ± 0.38 0.026 0.016 0.288
T-CDCA 20.82 ± 4.65 16.27 ± 2.36 15.21 ± 1.89 17.13 ± 3.64 0.741 0.457 0.397
T-HCA 9.60 ± 3.18 12.25 ± 5.24 7.779 ± 0.89 15.81 ± 3.97 0.133 0.889 0.465
T-HDCA 6.69 ± 1.76 9.29 ± 1.90 6.46 ± 1.12 12.77 ± 1.84 0.013 0.445 0.309
T-DCA BDL BDL BDL BDL n/a n/a n/a
T-LCA 0.003 ± 0.001 0.234 ± .020 BDL 0.027 ± 0.001 n/a n/a n/a
Total T-CONJ 42.70 ± 10.96 39.79 ± 7.57 31.19 ± 3.16 46.91 ± 9.45 0.421 0.723 0.306
Total 129.02 ± 28.52 141.42 ± 16.89 119.05 ± 11.15 179.64 ± 29.82 0.125 0.647 0.346

Data are shown as means ± SE in units—nmol/g liver tissue. Bile acid profile (nmol/g liver tissue), including unconjugated (UN-CONJ), taurine conjugated (T-CONJ), and glycine conjugated (G-CONJ) species, of liver tissue of preterm (P) and term (T) pigs at birth and day 3 (Preterm-Birth, n = 9, Preterm-Day 3, n = 9, Term-Birth, n = 6, Term-Day 3, n = 8). BDL, below detectable limits; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GA, gestational age; HCA, hyocholic acid; HDCA, hyodeoxycholic acid; LCA, lithocholic acid; n/a, not applicable; UDCA, ursodeoxycholic acid. a,bP (GA × Day) < 0.05.