Figure 1.

At index (yellow oval) and each follow-up time point (blue ovals), central nervous system (CNS)-active medication use was defined as having any prescription fill coverage overlapping with the period 30 days prior to each time point (dotted line in figure). This measure takes into account adherence and early refills. The green bars in the box below show three different example scenarios of prescription fills: 1) the medication fill is completed prior to the 30 day window which is considered not current use; 2) the medication fill overlaps the 30 day window which is considered current use; and 3) the medication fill starts within the 30 day window which is considered current use.