Table 2.
Unadjusted results: Characteristics associated with pretreatment LSA score and monthly changes from 0-1 mo and 1-6 mo after initiation of NSCLC treatment (N=93).
| Characteristic | Mean pretreatment LSA score (95% CI) | P a | Pretreatment to 1 mo change in LSA score (95% CI) | P a | 1-6 months change/month in LSA score (95% CI) | P a |
|---|---|---|---|---|---|---|
| Demographic and clinical characteristics | ||||||
| Race | ||||||
| White | 77.8 (70.9, 84.6) | Ref | −11.6 (−16.8, −6.4) | Ref | 1.3 (−0.17, 2.7) | Ref |
| Asian | 45.5 (34.7, 56.3) | <0.001 | −8.1 (−16.3, 0.1) | 0.48 | 0.9 (−1.2, 3.0) | 0.78 |
| Other | 55.9 (39.2, 72.7) | 0.02 | −6.3 (−19.1, 6.5) | 0.44 | −1.5 (−4.7, 1.7) | 0.13 |
| Primary language | ||||||
| English | 72.1 (65.9, 78.4) | Ref | −10.8 (−15.3, −6.2) | Ref | 0.7 (−0.5, 1.9) | Ref |
| Chinese | 38.4 (23.6, 53.2) | <0.001 | −6.2 (−16.8, 4.5) | 0.44 | 1.4 (−1.5, 4.3) | 0.66 |
| Education | ||||||
| ≤High school | 48.9 (37.1, 60.8) | Ref | −15.0 (−24.2, −5.8) | Ref | 2.0 (−0.6, 4.7) | Ref |
| College | 72.8 (64.3, 81.3) | 0.001 | −4.6 (−10.8, 1.6) | 0.07 | 0.9 (−0.6, 2.4) | 0.47 |
| Graduate | 75.9 (65.5, 86.2) | 0.001 | −11.8 (−19.6, −4.0) | 0.60 | −1.0 (−3.3, 1.3) | 0.09 |
| Smoking status | ||||||
| Former | 72.6 (65.1, 80.0) | Ref | −10.9 (−16.0, −5.7) | Ref | 1.4 (−0.1, 2.5) | Ref |
| Never | 57.2 (46.5, 67.8) | 0.02 | −7.4 (−14.9, −0.03) | 0.46 | −0.8 (−2.8, 1.2) | 0.07 |
| Current | 59.6 (33.9, 85.3) | 0.34 | −21.1 (−41.8, −0.3) | 0.35 | 9.6 (−18.1, 37.4) | 0.56 |
| Adenocarcinoma histology | ||||||
| No | 50.9 (36.5, 65.4) | Ref | −10.3 (−20.3, −0.4) | Ref | 2.5 (−0.2, 5.2) | Ref |
| Yes | 70.4 (63.8, 77.0) | 0.02 | −10.0 (−14.6, −5.5) | 0.96 | 0.4 (−0.8, 1.7) | 0.18 |
| Prior surgery | ||||||
| No | 64.2 (57.6, 70.9) | Ref | −9.8 (−14.4, −5.2) | Ref | 0.8 (−0.5, 2.0) | Ref |
| Yes | 80.6 (66.1, 95.2) | 0.045 | −11.8 (−21.7, −2.0) | 0.71 | 0.9 (−1.7, 3.4) | 0.93 |
| Pretreatment geriatrics assessment and symptom characteristics | ||||||
| Provider-rated Karnofsky Performance Status <70 | ||||||
| No | 71.0 (64.7, 77.3) | Ref | −10.2 (−14.7, −5.7) | Ref | 0.9 (−0.3, 2.1) | Ref |
| Yes | 42.8 (27.2, 58.4) | 0.001 | −9.8 (−21.0, 1.4) | 0.95 | 0.1 (−3.0, 3.3) | 0.67 |
| Dependent in ≥1 activities of daily living | ||||||
| No | 72.0 (65.5, 78.4) | Ref | −9.4 (−14.1, −4.8) | Ref | 0.5 (−0.7, 1.7) | Ref |
| Yes | 46.7 (33.5, 59.8) | 0.001 | −13.4 (−23.0, −3.7) | 0.47 | 2.1 (−1.0, 5.2) | 0.35 |
| Dependent in ≥1 instrumental activities of daily living | ||||||
| No | 87.9 (78.7, 97.2) | Ref | −6.2 (−13.7, 1.3) | Ref | −0.2 (−2.0, 1.7) | Ref |
| Yes | 58.6 (52.0, 65.2) | <0.001 | −11.1 (−16.4, −5.9) | 0.30 | 1.3 (−0.1, 2.7) | 0.24 |
| Timed Up and Go ≥13.5 seconds | ||||||
| No | 74.8 (67.9, 81.7) | Ref | −7.6 (−12.8, −2.5) | Ref | 1.2 (−0.2, 2.5) | Ref |
| Yes | 58.8 (49.1, 68.6) | 0.01 | −15.9 (−23.2, −8.5) | 0.07 | −0.2 (−2.1, 1.8) | 0.28 |
| Short Physical Performance Battery ≤9 | ||||||
| No | 77.8 (70.1, 85.5) | Ref | −9.8 (−15.4, −4.2) | Ref | 0.9 (−0.5, 2.3) | Ref |
| Yes | 54.6 (46.3, 62.9) | <0.001 | −10.7 (−16.9, −4.5) | 0.83 | 0.5 (−1.3, 2.3) | 0.73 |
| ≥3 comorbidities | ||||||
| No | 75.0 (67.8, 82.2) | Ref | −7.2 (−12.4, −1.9) | Ref | 0.3 (−1.1, 1.6) | Ref |
| Yes | 54.5 (45.4, 63.5) | 0.001 | −15.4 (−22.2, −8.6) | 0.06 | 1.7 (−0.2, 3.7) | 0.23 |
| Low hemoglobin (<10 g/dL for women, <11 g/dL for men) | ||||||
| No | 70.0 (63.8, 76.2) | Ref | −10.0 (−14.5, −5.6) | Ref | 0.7 (−0.4, 1.9) | Ref |
| Yes | 42.6 (25.8, 59.4) | 0.003 | −12.7 (−24.8, −0.6) | 0.69 | 0.9 (−3.5, 5.3) | 0.96 |
| Body mass index <21 kg/m2 | ||||||
| No | 66.8 (59.9, 73.7) | Ref | −9.0 (−13.7, −4.3) | Ref | −0.04 (−1.3, 1.2) | Ref |
| Yes | 67.9 (54.7, 81.1) | 0.89 | −13.9 (−22.5, −5.2) | 0.34 | 4.1 (1.6, 6.5) | 0.003 |
| Involuntary weight loss in last 6 months | ||||||
| No | 77.5 (68.0, 87.0) | Ref | −9.2 (−16.0, −2.4) | Ref | 0.4 (−1.2, 2.1) | Ref |
| Yes | 62.3 (54.2, 70.3) | 0.02 | −10.0 (−15.7, −4.2) | 0.87 | 1.1 (−0.5, 2.6) | 0.59 |
| MHI-13 depression score ≥12 | ||||||
| No | 77.2 (69.3, 85.1) | Ref | −6.5 (−12.4, −0.6) | Ref | 0.5 (−0.9, 1.9) | Ref |
| Yes | 61.4 (51.6, 71.3) | 0.01 | −14.8 (−22.1, −7.5) | 0.08 | 1.8 (−0.4, 3.9) | 0.33 |
| MHI-13 anxiety score ≥6 | ||||||
| No | 80.7 (69.0, 92.3) | Ref | −2.3 (−11.0, 6.4) | Ref | 0.2 (−2.0, 2.4) | Ref |
| Yes | 67.2 (59.9, 74.5) | 0.06 | −12.6 (−18.0, −7.2) | 0.048 | 1.3 (−0.1, 2.7) | 0.43 |
| High morning fatigue | ||||||
| No | 79.4 (72.2, 86.5) | Ref | −7.5 (−13.3, −2.0) | Ref | 0.1 (−1.2, 1.7) | Ref |
| Yes | 52.4 (43.4, 61.4) | <0.001 | −12.5 (−19.7, −5.3) | 0.30 | 1.8 (−0.1, 3.7) | 0.20 |
| Pain | ||||||
| No | 74.0 (66.7, 81.3) | Ref | −8.9 (−14.3, −3.5) | Ref | 0.7 (−0.6, 2.0) | Ref |
| Yes | 54.8 (42.6, 66.9) | 0.008 | −10.7 (−19.6, −1.8) | 0.74 | 0.7 (−2.0, 3.5) | 0.99 |
Abbreviations: CI, confidence interval; g/dL, gram per deciliter; kg/m2, kilogram per meter squared; MHI, Mental Health Inventory; Ref, reference.
a
P-values <0.05 are in bold.