Table 3.
Adjusteda associations with pretreatment LSA score and monthly changes from 0-1 mo and 1-6 mo after initiation of NSCLC treatment (N=93).
| Characteristic | Mean pretreatment LSA score (95% CI) | P b | Pretreatment to 1 mo change in LSA score (95% CI) | P b | 1-6 mo change/mo in LSA score (95% CI) | P b |
|---|---|---|---|---|---|---|
| Provider-rated Karnofsky Performance Status <70 | ||||||
| No | 84.3 (75.5, 93.1) | Ref | −10.3 (−14.8, −5.8) | Ref | 0.9 (−0.3, 2.1) | Ref |
| Yes | 70.9 (53.6, 88.2) | 0.10 | −9.3 (−20.5, 2.0) | 0.86 | 0.3 (−2.8, 3.4) | 0.72 |
| Dependent in ≥1 activities of daily living | ||||||
| No | 85.0 (76.3, 93.6) | Ref | −9.6 (−14.2, −4.9) | Ref | 0.5 (−0.7, 1.7) | Ref |
| Yes | 70.0 (55.1, 84.8) | 0.03 | −13.2 (−22.8, −3.5) | 0.51 | 2.3 (−0.7, 5.4) | 0.28 |
| Dependent in ≥1 instrumental activities of daily living | ||||||
| No | 97.2 (87.6, 106.9) | Ref | −6.6 (−14.1, 1.0) | Ref | −0.2 (−2.1, 1.7) | Ref |
| Yes | 73.9 (65.3, 82.5) | <0.001 | −11.2 (−16.5, −5.9) | 0.32 | 1.4 (−0.04, 2.8) | 0.19 |
| Timed Up and Go ≥13.5 seconds | ||||||
| No | 84.9 (76.5, 93.4) | Ref | −7.7 (−12.9, −2.5) | Ref | 1.2 (−0.2, 2.5) | Ref |
| Yes | 75.9 (63.9, 87.8) | 0.11 | −16.2 (−23.5, −8.9) | 0.06 | −0.1 (−2.0, 1.9) | 0.31 |
| Short Physical Performance Battery ≤9 | ||||||
| No | 89.1 (80.0, 98.2) | Ref | −10.0 (−15.6, −4.4) | Ref | 1.0 (−0.5, 2.4) | Ref |
| Yes | 73.2 (62.8, 83.7) | 0.002 | −10.6 (−16.8, −4.3) | 0.89 | 0.5 (−1.2, 2.3) | 0.71 |
| ≥3 comorbidities | ||||||
| No | 87.2 (78.5, 95.9) | Ref | −7.5 (−12.7, −2.2) | Ref | 0.2 (−1.1, 1.6) | Ref |
| Yes | 73.1 (62.1, 84.1) | 0.01 | −15.1 (−21.9, −8.3) | 0.08 | 1.8 (−0.1, 3.8) | 0.19 |
| Low hemoglobin (<10 g/dL for women, <11 g/dL for men) | ||||||
| No | 84.5 (75.9, 93.1) | Ref | −9.4 (−14.7, −5.7) | Ref | 0.8 (−0.4, 1.9) | Ref |
| Yes | 68.5 (50.7, 86.2) | 0.05 | −10.4 (−24.6, −0.4) | 0.72 | 1.2 (−3.2, 5.6) | 0.84 |
| Involuntary weight loss in last 6 months | ||||||
| No | 88.9 (78.3, 99.5) | Ref | −9.6 (−16.3, −2.8) | Ref | 0.4 (−1.3, 2.0) | Ref |
| Yes | 81.2 (71.2, 91.1) | 0.19 | −10.0 (−15.8, −4.3) | 0.92 | 1.2 (−0.4, 2.8) | 0.47 |
| Body mass index <21 kg/m2 | ||||||
| No | 83.3 (73.4, 93.3) | Ref | −9.1 (−13.8, −4.4) | Ref | 0.02 (−1.2, 1.2) | Ref |
| Yes | 83.8 (71.5, 96.0) | 0.95 | −13.9 (−22.5, −5.2) | 0.34 | 3.7 (1.5, 6.5) | 0.004 |
| MHI-13 depression score ≥12 | ||||||
| No | 90.6 (82.3, 99.0) | Ref | −6.8 (−12.7, −1.0) | Ref | 0.5 (−1.0, 1.9) | Ref |
| Yes | 79.9 (69.6, 90.3) | 0.04 | −15.0 (−22.3, −7.6) | 0.09 | 1.7 (−0.4, 3.9) | 0.33 |
| MHI-13 anxiety score ≥6 | ||||||
| No | 88.3 (77.2, 99.4) | Ref | −2.2 (−11.0, 6.5) | Ref | 0.2 (−2.0, 2.4) | Ref |
| Yes | 86.7 (77.5, 95.9) | 0.79 | −13.0 (−18.4, −7.6) | 0.04 | 1.3 (−0.1, 2.7) | 0.45 |
| High morning fatigue | ||||||
| No | 89.9 (81.6, 98.1) | Ref | −8.0 (−13.7, −2.4) | Ref | 0.2 (−1.2, 1.7) | Ref |
| Yes | 72.2 (61.5, 82.9) | 0.001 | −12.6 (−19.8, −5.4) | 0.33 | 1.9 (−0.004, 3.7) | 0.18 |
| Pain | ||||||
| No | 89.2 (80.6, 97.9) | Ref | −9.3 (−14.7, −3.9) | Ref | 0.7 (−0.6, 2.0) | Ref |
| Yes | 74.4 (62.3, 86.5) | 0.02 | −10.5 (−19.4, −1.6) | 0.83 | 0.7 (−2.0, 3.4) | 1.00 |
Abbreviations: CI, confidence interval; g/dL, gram per deciliter; kg/m2, kilogram per meter squared; LSA, life-space assessment; MHI, Mental Health Inventory; ml/min, milliliters per minute; mo, month; NSCLC, non-small cell lung cancer.
a
Each geriatric assessment characteristic is tested in a separate linear mixed-effects model adjusted for race, education, histology, and prior surgery. Multiple imputation was used to estimate education for 12 patients. Results shown set covariates to the following values: white race, college education, adenocarcinoma histology, no prior surgery.
b
P-values <0.05 are in bold.