Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 8;9:2. doi: 10.1186/s40580-021-00293-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — Schematic diagram of the synthesis, dual-model imaging, and combination therapy of multifunctional platform SMID. Upper: The silk fibroin (SF) is extracted from the silkworm cocoon and self-assembles into SF nanoparticles. The surface of SF nanoparticles is biomineralized by MnO₂ (SF@MnO₂). ICG and DOX are both loaded onto SF@MnO₂ (SMID); Bottom: After intravenous injection, the tumor sites of mice are irradiated with a near-infrared (NIR) laser. The Mn²⁺ is produced under an acidic microenvironment, and ICG makes SMID an appropriate contrast agent for MR/fluorescence imaging. DOX and ICG is used for chemotherapy and photodynamic/photothermal therapy, respectively [166]