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. 2022 Jan 8;9:2. doi: 10.1186/s40580-021-00293-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Schematic illustration of the therapy and the therapeutic effect of the tumor [168]. Upper: Schematic illustration of the construction of dual antigens loaded HBc VLP and the subcutaneous inoculation; Bottom left: Results of treatment of lung metastases. Compared to saline and single antigen-loaded VLPs, hybrid VLPs significantly inhibited the lung metastasis of melanoma; Bottom right: Results of treatment of subcutaneous melanoma. Compared to saline and single antigen-loaded VLPs, hybrid VLPs inhibited tumor growth and reduced the tumor volume to the maximum extent