Table 3.

Clinical trials of protein nanoparticles applied for cancer therapy

Protein nanoparticles	Tumor type	Clinical studies	Year	Database (ID)
Albumin	Lung cancer	ABI-007 in Treating Patients with Chemotherapy-Naïve Stage IV Non-Small Cell Lung Cancer	2003–2008	ClinicalTrials.gov (NCT00077246)
Albumin	Ovarian cancer, fallopian tube cancer, and peritoneal cancer	Sargramostim and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients with Advanced Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer That Did Not Respond to Previous Chemotherapy	2006–2011	ClinicalTrials.gov (NCT00466960)
Albumin	Solid tumors	Recombinant EphB4-HSA Fusion Protein with Standard Chemotherapy Regimens in Treating Patients with Advanced or Metastatic Solid Tumors	2015-	ClinicalTrials.gov (NCT02495896)
Albumin	Breast cancer	Romidepsin and Abraxane in Treating Patients with Metastatic Inflammatory Breast Cancer	2014–2016	ClinicalTrials.gov (NCT01938833)
Albumin	Pancreatic cancer	Gemcitabine, Nab-paclitaxel and KPT-330 in Advanced Pancreatic Cancer	2014-	ClinicalTrials.gov (NCT02178436)
Albumin	Melanoma	ABI-007 in Treating Patients with Inoperable Locally Recurrent or Metastatic Melanoma	2004–2010	ClinicalTrials.gov (NCT00081042)