Table 2.
Case | Imatinib dosage at diagnosis | Imatinib dosage at follow-up | CCR (months from imatinib) | CMR (months from imatinib) | Relapse | Last follow-up (months after imatinib) |
---|---|---|---|---|---|---|
1 | 100 mg | 200 mg | + 24 | + 24 | No | + 30a |
2 | 100 mg | 100 mg | + 4 | + 18 | No | + 30a |
3 | 400 mg | 200 mg | + 1 | + 25 | No | + 222a |
4 | 100 mg | 100 mg | + 9 | + 9 | No | + 61a |
5 | n.a | n.a | + 11 | n.a | n.a | + 33* |
6 | 100 mg | 200 mg | + 24 | n.a | No | + 155* |
7 | 100 mg | 200 mg | + 8 | + 32 | No | + 109a |
8 | 100 mg | 200 mg | + 40§ | + 40§ | No | + 42a |
9 | 400 mg | 100 mg | + 12 | + 44 | No | + 129† |
11 | 100 mg | 200 mg | + 12 | No | No | + 72a |
12 | n.a | n.a | Maintained after CHT | Maintained after CHT | B-ALL | + 11† |
13 | 400 mg | 400 mg | + 4 | No | No | + 9† |
14 | 400 mg | 400 mg | + 7 | + 10# | AML | + 36† |
CCR complete cytogenetic remission, CMR complete molecular remission, CHT chemotherapy, B-ALL B cell acute lymphoblastic leukemia, n.a. not available
aAlive
§First evaluation after treatment
#Obtained after 8 months of imatinib therapy followed by 2 months of induction chemotherapy
†Death
*Lost at follow up