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. 2021 Dec 28;143(2):287–290. doi: 10.1007/s00401-021-02400-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — APPPS1 mice exhibit an age-dependent increase of p217 + tau in the CSF. Male and female APPPS1 at the age of 1.5, 3, 6, 12, 18 and 20–22 months (8–11 mice/group) and non-tg littermates (5–10 mice/group) were used. This is a new cohort of mice and different from the one shown in Fig. 1. a Two-way ANOVA revealed a significant age × genotype interaction (F[5, 95] = 41.7; p < 0.0001). CSF p217 + tau was significantly increased starting from 6 months on compared to the youngest group, however, only at 12 months of age there was a significant difference between APPPS1 and non-tg littermates (Tukey post hoc test, p < 0.0001 for both). b One-way ANOVA revealed a significant age effect on p217 + tau/t-tau ratio in APPPS1 mice (F[5, 48] = 16.5, p < 0.0001). For t-tau see Supplementary Fig. 1, online resource. CSF p217 + tau/t-tau increased between 6 and 12 months of age (Tukey test, p = 0.0043) reaching an apparent plateau. Shown are the geometric means ± confidence interval; statistics in a and b are based on log transformed values. c The relationship between CSF p217 + tau and t-tau showed a strong positive correlation (Spearman rank correlation test: ρ = 0.94, p < 0.0001)