Fig. 3.

ADanPP mice exhibit an age-dependent increase of p217 + tau in the CSF. Male and female ADanPP and non-tg littermates at the age of 3, 12–13, and 18–21 months (6–9 mice/group) were used. a Two-way ANOVA revealed a significant age × genotype interaction (F[2, 37] = 15.4; p < 0.0001). At 12–13 months of age, CSF p217 + tau was already significantly increased compared to the youngest group and age-matched non-tg littermates (Tukey post hoc test, p < 0.0001 and p = 0.0008, respectively). b One-way ANOVA revealed a significant age effect on p217 + tau/t-tau ratio (F[2, 19] = 18.15, p < 0.0001) with significant increases in the 12–13- and 18–20-month-old ADanPP mice compared to the youngest age group (Tukey test, p = 0.0004 and p < 0.0001, respectively; note that one value > 1 in the oldest age group was excluded from the statistical analysis because p217 + tau values above 100% of t-tau are not scientifically reasonable). For t-tau see Supplementary Fig. 1, online resource. Shown are the geometric means ± confidence interval, statistics in a and b are based on log transformed values. c The relationship between CSF p217 + tau and t-tau showed a strong positive correlation (Spearman rank correlation test: ρ = 0.89, p < 0.0001). Log10 scale was used on x- and y-axis