Table 1.
Fulfilment of two sets of classification criteria in all patients with diagnosed GCA, by confirmation of GCA diagnosis and by phenotype of GCA.
| Criteria | All, n (%) | Confirmed GCA, n (%) | Rejected GCA, n (%) | P- value | Cranial, n (%) | Constitutional, n (%) | P- value |
|---|---|---|---|---|---|---|---|
| ACR 1990 [7] | 156 (85.2) | 108 (93.1) | 48 (71.6) | <0.001 | 85 (95.5) | 20 (90.9) | 1 |
| Age at disease onset ≥50 years | 183 (100) | 116 (100) | 67 (100) | NA | 89 (100) | 22 (100) | NA |
| Localized pain in the head | 145 (79.2) | 94 (81.0) | 51 (76.1) | 0.43 | 81 (91.0) | 11 (50.0) | <0.001 |
| Temporal artery abnormality | 108 (59.0) | 61 (53.0) | 47 (70.1) | 0.02 | 54 (60.7) | 7 (33.3) | 0.02 |
| Elevated ESRa | 117 (63.9) | 88 (75.9) | 29 (43.3) | <0.001 | 62 (69.7) | 21 (95.5) | 0.01 |
| Abnormal artery biopsy | 79 (43.2) | 79 (68.1) | 0 (0) | <0.001 | 59 (66.3) | 17 (77.2) | 0.32 |
| Revised (Dejaco et al. [3]) | 88 (48.1) | 84 (72.4) | 4 (6.0) | <0.001 | 60 (67.4) | 19 (86.4) | 0.08 |
| Age at disease onset ≥50 years | 183 (100) | 116 (100) | 67 (100) | NA | 89 (100) | 22 (100) | NA |
| Localized pain in the headb | 180 (98.4) | 114 (98.3) | 66 (98.5) | 1 | 89 (100) | 22 (100) | NA |
| Temporal artery abnormalityc | 111 (60.7) | 64 (55.2) | 47 (70.1) | 0.046 | 54 (60.7) | 9 (40.9) | 0.09 |
| Elevated ESRa and/or CRPd | 159 (86.9) | 110 (94.8) | 49 (73.1) | <0.001 | 83 (93.3) | 22 (100) | 0.60 |
| Abnormal artery biopsy revised e | 88 (48.1) | 84 (72.4) | 4 (6.0) | <0.001 | 60 (67.4) | 19 (86.4) | 0.08 |
a
ESR ≥50 mm/h. Revised criteria also included
b
visual symptoms, sight loss, PMR, constitutional symptoms, jaw and/or tongue claudication;
c
abnormality of extracranial arteries;
d
CRP ≥10 mg/l;
eabnormal artery biopsy or :abnormal imaging result (ultrasound, MRI and/or 18-FDG PET).
P-values are not corrected for multiple comparisons. The phenotypes large vessel GCA and isolated PMR are excluded due to too few cases. NA: not applicable.