Table 3.
Axis-based analysis of cause-specific mortality in early and late cohorts
| Overall |
Axis-based analysis |
||||||
|---|---|---|---|---|---|---|---|
| Variables |
Early cohort (1997–2005) |
Late cohort (2006–14) |
|||||
| SLE (N = 6092) |
Non-SLE (N = 60 920) | SLE (N = 2794) |
Non-SLE (N = 27 940) | SLE (N = 3298) |
Non-SLE (N = 32 980) | P for interaction | |
| Total follow up (person-years) | 24 860.54 | 254 403.92 | 11 212.67 | 116 168.77 | 13 647.87 | 138 235.15 | N/A |
| Mean follow-up (years) | 4.08 | 4.18 | 4.01 | 4.16 | 4.14 | 4.19 | N/A |
| Renal disease mortality | |||||||
| Deaths | 76 | 172 | 39 | 74 | 37 | 98 | N/A |
| MR (cases per 1000 person-years) | 3.06 | 0.68 | 3.48 | 0.64 | 2.71 | 0.71 | N/A |
| Age-, sex- and entry time-adjusted HR (95% CI) |
4.73 (3.59, 6.22) |
1 |
5.74 (3.86, 8.52) |
1 |
3.99 (2.72, 5.85) |
1 | 0.20 |
| Fully adjusted HRa (95% CI) |
3.04 (2.29, 4.05) |
1 |
3.57 (2.37, 5.36) |
1 |
2.65 (1.78, 3.93) |
1 | 0.30 |
| Cancer mortality | |||||||
| Deaths | 109 | 748 | 57 | 372 | 52 | 376 | N/A |
| MR (deaths per 1000 person-years) | 4.38 | 2.94 | 5.08 | 3.20 | 3.81 | 2.72 | N/A |
| Age-, sex- and entry time-adjusted HR (95% CI) |
1.56 (1.28, 1.91) |
1 |
1.69 (1.28, 2.24) |
1 |
1.44 (1.08, 1.93) |
1 | 0.45 |
| Fully adjusted HRa (95% CI) |
1.18 (0.96, 1.46) |
1 |
1.27 (0.96, 1.69) |
1 |
1.10 (0.82, 1.48) |
1 | 0.48 |
| Infection mortality | |||||||
| Deaths | 113 | 332 | 60 | 175 | 53 | 157 | N/A |
| MR (cases per 1000 person-years) | 4.55 | 1.31 | 5.35 | 1.51 | 3.88 | 1.14 | N/A |
| Age-, sex- and entry time-adjusted HR (95% CI) |
3.85 (3.10, 4.79) |
1 |
4.11 (3.05, 5.55) |
1 |
3.62 (2.64, 4.95) |
1 | 0.56 |
| Fully adjusted HRa (95% CI) |
2.74 (2.19, 3.43) |
1 |
2.94 (2.17, 3.98) |
1 |
2.54 (1.84, 3.51) |
1 | 0.52 |
| CVD mortality | |||||||
| Deaths | 246 | 916 | 132 | 535 | 114 | 381 | N/A |
| MR (cases per 1000 person-years) | 9.90 | 3.60 | 11.77 | 4.61 | 8.35 | 2.76 | N/A |
| Age-, sex- and entry time-adjusted HR (95% CI) |
2.96 (2.57, 3.42) |
1 |
2.82 (2.32, 3.42) |
1 |
3.17 (2.57, 3.92) |
1 | 0.42 |
| Fully adjusted HRa (95% CI) |
2.05 (1.77, 2.38) |
1 |
1.95 (1.60, 2.38) |
1 |
2.18 (1.76, 2.71) |
1 | 0.45 |
| Other causes | |||||||
| Deaths | 366 | 1281 | 203 | 682 | 163 | 599 | N/A |
| MR (cases per 1000 person-years) | 14.72 | 5.04 | 18.10 | 5.87 | 11.94 | 4.33 | N/A |
| Age-, sex- and entry time-adjusted HR (95% CI) |
3.15 (2.80, 3.55) |
1 |
3.40 (2.90, 3.99) |
1 |
2.90 (2.44, 3.45) |
1 | 0.18 |
| Fully adjusted HRa (95% CI) |
2.19 (1.94, 2.47) |
1 |
2.34 (1.99, 2.76) |
1 |
2.03 (1.69, 2.42) |
1 | 0.24 |
In addition to matching variables (age, sex and entry time), fully adjusted models were adjusted for the number of medical visits.
CVD: cardiovascular disease; MR: mortality rate; HR: hazard ratio; N/A: not applicable.