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. 2021 Dec 30;5(3):e202101225. doi: 10.26508/lsa.202101225

Figure 6. An unidentified microtubule inner protein (MIP) at the inner junction of the doublet microtubule.

Figure 6.

(A) An unidentified MIP (royal blue) in the inner junction region of DMT. In the cartoon, an arrowhead indicates the direction of view of the MIP. This multi-domain MIP spans several protofilaments, from B07 to A13, longitudinally repeating every 48 nm. (B) An unidentified MIP (royal blue) makes extensive interactions with multiple protofilaments and other MIPs at the inner junction. On the left, the plus end of DMT is towards the left as indicated. Two FAP52 (red) are shown. A FAP106 is behind the unidentified MIP (not shown). Three FAP45 are shown. FAP45 #1 (dark orange) and FAP45 #3 (yellow) bind on the cleft between protofilament B07/B08 and B08/B09, respectively. The α-helical FAP45 #2 (orange) initiates from the pf B09, threads through a gap between FAP52 and the unidentified MIP (indicated by an arrow), makes two ∼90° turns (indicated by two asterisks). FAP45 #2 interacts with FAP45 #3 and FAP45 #1 before landing on the cleft between pf B07/B08. Two FAP210 are shown in green. The inset shows a magnified view of the described interactions among the unidentified MIP (royal blue), FAP45 #2 and other nearby MIPs.