Table 3.

Univariate and multivariate COX regression analyses identify clinical factors associated with prognosis

Variables	Univariate analysis			Multivariable analysis
	HR	95% CI of HR	p-value	HR	95% CI of HR	p-value
Entire TCGA cohort
4-mRNA risk score
Risk score (high/low)	2.684	1.865–3.864	1.07 × 10−7	2.558	1.673–3.913	1.47 × 10−5
Age	1.008	0.994–1.022	0.252	1.005	0.989–1.021	0.541
Gender (male/female)	0.804	0.556–1.163	0.247	0.812	0.541–1.218	0.314
AFP	1.067	0.642–1.775	0.801	—	—	—
T3/T4 vs T1/T2	2.901	2.016–4.176	9.90 × 10−9	2.791	0.357–21.833	0.328
N1/N2 vs N0	1.559	1.066–2.280	0.022	1.053	0.629–1.763	0.845
M1/MX vs M0	1.732	1.184–2.533	0.005	1.814	1.104–2.979	0.019
Stage III/IV vs stage I/II	2.827	1.923–4.154	1.23 × 10−7	0.922	0.119–7.165	0.938
G3/G4 vs G1/G2	1.085	0.745–1.578	0.671	0.946	0.612–1.462	0.802
ICGA cohort
4-mRNA risk score
Risk score (high/low)	3.038	1.551–5.949	0.0012	2.984	1.506–5.913	0.0017
Age	1.015	0.979–1.052	0.406	1.007	0.971–1.045	0.691
Gender (male/female)	0.516	0.256–1.039	0.064	0.337	0.156–0.733	0.006
Stage III/IV vs stage I/II	2.737	1.415–5.295	0.0028	3.282	1.624–6.632	0.0009