Table 1.
Neutralization of SARS-CoV-2 virus by selected sera in cell culture. High blocking titres indicate neutralizing activity, neutralizing sera highlighted with orange. Sera were selected according to identified levels of SARS-CoV-2 protein-specific IgG specified in the column ‘IgG antibodies status’ (for details see Table S1)
|
Sample ID |
SARS-CoV-2 blocking titre |
SARS-CoV-2 infection |
IgG antibodies status |
|---|---|---|---|
|
COV15 |
320 |
Infection confirmed |
Positive control (all types high) |
|
COV11 |
640 |
Infection confirmed |
Positive control (all types high) |
|
COV18 |
80 |
Infection confirmed |
Positive control (all types high) |
|
HIS178 |
5 |
Historical collection of sera (2017) |
Negative control (all types low) |
|
371 |
5 |
Healthy/undiagnosed |
Negative control (all types low) |
|
366 |
5 |
Healthy/undiagnosed |
Negative control (all types low) |
|
COV3 |
2560 |
Infection confirmed |
Anti-N high |
|
COV24A |
80 |
Infection confirmed |
Anti-N high |
|
COV22 |
80 |
Infection confirmed |
Anti-N high |
|
HIS114 |
5 |
Historical collection of sera (2017) |
Anti-S1 high |
|
HIS119 |
5 |
Historical collection of sera (2017) |
Anti-S1 high |
|
348 |
5 |
Healthy/undiagnosed |
Anti-S1 high |
|
310 |
5 |
Healthy/undiagnosed |
Anti-E high |
|
COV7 |
5 |
Infection confirmed |
Anti-E high |
|
262 |
5 |
Healthy/undiagnosed |
Anti-E high |
anti-E high, high level of IgG specific to E protein; anti-N high, high level of IgG specific to N protein; anti-S1 high, high level of IgG specific to S1 protein; negative control, all types of IgG at low levels; Positive control, all types of IgG at high levels.