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. 2021 Sep 9;31(2):244–261. doi: 10.1093/hmg/ddab244

Figure 5.

Figure 5

Immunofluorescence analysis of PHF-Tau (AT8). The effect of ligand 1 on phosphorylated tau using AT8 antibody immunofluorescence analysis on four different groups of cells: 1) HT22 cells (control); 2) control+ligand 1; 3) mutant Tau and 4) mutant Tau+ligand 1. Statistical significance phosphorylated tau levels were significantly increased in Mutant tau HT22cells when compared with control (P = 0.01). Reduced PHF-Tau in ligand 1 treated HT22 cells with control cells (P = 0.01). Decreased PHF-tau protein observed in mutant Tau+ligand 1 mutant Tau (P = 0.03). Scale bar 20 μM.