Panel 3.

Future Research Topics Ranked of Highest Importance

Screening and diagnosis of CS

• Optimize pituitary MR and PET imaging using improved data acquisition and processing to improve microadenoma detection

• Compare diagnostic algorithms for the differential diagnosis using invasive versus non-invasive strategies

• Identify additional corticotroph adenoma mutations and development of a comprehensive panel of genomic/proteomic tests for CD diagnosis

Complications of CD

• Define use of anticoagulant prophylaxis and therapy in different populations and settings

• Optimize the approach in managing long-term complications

Treatment of CD

• Determine clinical benefit of restoring the circadian rhythm, potentially with a higher nighttime medication dose

• Identify better markers of disease activity and control

• Develop new, better tolerated, more effective medical therapies

• Define populations that might benefit from preoperative medical treatment

Abbreviations: CD, Cushing’s disease; CS, Cushing’s syndrome; MR, magnetic resonance; PET, positron emission tomography.